{"id":"W4391221244","doi":"10.3390/cells13030229","title":"Oncostatin M and STAT3 Signaling Pathways Support Human Trophoblast Differentiation by Inhibiting Inflammatory Stress in Response to IFNγ and GM-CSF","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique; Université du Québec à Trois-Rivières; Université du Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Ministère des relations internationales et de la Francophonie","keywords":"Oncostatin M; Trophoblast; SOCS3; Cell biology; Biology; STAT1; Cytokine; Signal transduction; STAT3; Immunology; Interleukin 6; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007025527,0.0001720399,0.0001102693,0.0001432849,0.00009535361,0.0002052426,0.00007421475,0.0001191488,0.001666741],"category_scores_gemma":[0.00007349681,0.00007871363,0.0002254875,0.0001087881,0.0001514151,0.0001126892,0.0001836935,0.0003569329,0.0003228715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443754,"about_ca_system_score_gemma":0.0002924677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004976813,"about_ca_topic_score_gemma":0.0008077517,"domain_scores_codex":[0.999929,0.00001033706,0.00000728964,0.000008736763,0.00002141274,0.00002327054],"domain_scores_gemma":[0.9999534,0.00000708346,0.00001634904,0.00000570132,0.000003890017,0.0000135268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002215315,0.00001904878,0.0003004407,0.00003354461,0.000002954025,0.00004632416,0.00001599602,0.00005770564,0.9973999,0.0001296078,0.00008371982,0.001689211],"study_design_scores_gemma":[0.00004134476,0.0003403402,0.006797132,0.000007543996,0.00001653071,0.0003886421,0.00005260106,0.0007924693,0.9843081,0.0001053277,0.007147054,0.000003053243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921745,0.001845129,0.002156358,0.0001861163,0.00004679447,0.00002991086,0.0007233837,0.00009584237,0.002741894],"genre_scores_gemma":[0.994086,0.001108794,0.001491003,0.00007925376,0.00001170986,0.00003493432,0.001016551,0.00001320226,0.002158413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666741,"threshold_uncertainty_score":0.005575836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008889667951806327,"score_gpt":0.2271753707898695,"score_spread":0.2182857028380632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}