{"id":"W4391221244","doi":"10.3390/cells13030229","title":"Oncostatin M and STAT3 Signaling Pathways Support Human Trophoblast Differentiation by Inhibiting Inflammatory Stress in Response to IFNγ and GM-CSF","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique; Université du Québec à Trois-Rivières; Université du Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Québécois de la Recherche sur la Nature et les Technologies; Ministère des relations internationales et de la Francophonie","keywords":"Oncostatin M; Trophoblast; SOCS3; Cell biology; Biology; STAT1; Cytokine; Signal transduction; STAT3; Immunology; Interleukin 6; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005068129,0.0001499278,0.0002010387,0.0001586301,0.0001070539,0.00006247109,0.0000520649,0.0001144733,0.00009917268],"category_scores_gemma":[0.0000419149,0.0001402595,0.00002287939,0.00009056359,0.00006450653,0.0001133735,0.00006901255,0.0001893714,0.00006631234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003874535,"about_ca_system_score_gemma":0.00003718296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003582279,"about_ca_topic_score_gemma":0.00002445646,"domain_scores_codex":[0.9986024,0.0003825221,0.0003159847,0.0004301219,0.00003327368,0.0002357078],"domain_scores_gemma":[0.9995532,0.0002012131,0.00006017034,0.0001246046,0.00002894138,0.00003187434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001015752,0.00002287742,0.003778733,0.0001732616,0.00002301061,0.00002684508,0.006453067,0.000004318222,0.98626,0.00006769395,0.0008302078,0.002258401],"study_design_scores_gemma":[0.0006065429,0.0002504276,0.01182242,0.0005983274,0.00001375026,0.00001376515,0.001429407,0.000002172411,0.9825695,0.0001061005,0.002386422,0.0002011886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941743,0.00469252,0.00008757428,0.00006446075,0.0002813505,0.000320195,0.0001388454,0.00004803627,0.0001927153],"genre_scores_gemma":[0.9983693,0.00003159593,0.000021003,0.00002179504,0.00002953577,0.00002573463,0.00007928473,0.00001987563,0.001401847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00804369,"threshold_uncertainty_score":0.5719615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008889667951806327,"score_gpt":0.2271753707898695,"score_spread":0.2182857028380632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}