{"id":"W4391239487","doi":"10.1093/hmg/ddae006","title":"Removal of <i>pomt1</i> in zebrafish leads to loss of α-dystroglycan glycosylation and dystroglycanopathy phenotypes","year":2024,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; York University; Harvard University; Robert Wood Johnson Foundation; University of Oregon; Rutgers Cancer Institute of New Jersey","keywords":"Dystroglycan; Zebrafish; Biology; Phenotype; Congenital muscular dystrophy; Cell biology; Extracellular matrix; Genetics; Internal medicine; Muscular dystrophy; Gene; Laminin; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404908,0.0008540558,0.0003170554,0.0004803165,0.0003863983,0.0003548366,0.0006126764,0.0008014346,0.00214429],"category_scores_gemma":[0.000170965,0.0004462065,0.0005778166,0.0001298263,0.0005869743,0.0003018979,0.0005544992,0.001239271,0.0008000805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001096741,"about_ca_system_score_gemma":0.000773661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009428319,"about_ca_topic_score_gemma":0.01289979,"domain_scores_codex":[0.9997296,0.00001408459,0.00003829732,0.00007503338,0.00008925881,0.00005376845],"domain_scores_gemma":[0.9997302,0.00003330045,0.0001210827,0.0000213415,0.00001956261,0.00007452133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002551391,0.000005843165,0.00007061924,0.00001872225,0.000002789276,0.00009327707,0.00001265273,0.00003632904,0.9993991,0.00007828984,0.00002474266,0.0002321342],"study_design_scores_gemma":[0.00002475319,0.0001858291,0.004930386,0.00001593973,0.00003217314,0.0004133562,0.00004923652,0.0007576157,0.9905369,0.00006706801,0.002968211,0.00001858707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879118,0.0008714246,0.005252727,0.0004451758,0.0001151249,0.0001001929,0.001783609,0.0004087118,0.003111173],"genre_scores_gemma":[0.9819957,0.0007076209,0.004261725,0.0002519573,0.00001646023,0.0001114695,0.001094435,0.0002620911,0.01129857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009428319,"threshold_uncertainty_score":0.01874691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006510221723753347,"score_gpt":0.2514666825666585,"score_spread":0.2449564608429051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}