{"id":"W4391250445","doi":"10.1371/journal.ppat.1011557","title":"Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Malaria Research and Control","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires; Bundesministerium für Bildung und Forschung; China Scholarship Council; Fundação de Amparo à Pesquisa do Estado de São Paulo; Francis Crick Institute","keywords":"Geranylgeraniol; Mevalonate pathway; Biology; POLK; Farnesyl pyrophosphate; Biochemistry; Plasmodium falciparum; Biosynthesis; Farnesol; Cell biology; Enzyme; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006261793,0.0003854826,0.0002407987,0.0001134331,0.0001368212,0.000282333,0.0001327679,0.0002582961,0.0007846372],"category_scores_gemma":[0.00008589001,0.0001027388,0.0002055334,0.00009245604,0.0001692971,0.0003362859,0.0001612074,0.0003653148,0.0004765456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002437903,"about_ca_system_score_gemma":0.0001700045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000255022,"about_ca_topic_score_gemma":0.0003026105,"domain_scores_codex":[0.9999504,0.000007321051,0.000005021057,0.00001829993,0.00001063396,0.000008405434],"domain_scores_gemma":[0.9999555,0.00000633106,0.00001451627,0.000006624165,0.000005658874,0.00001141031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006567024,0.000005348688,0.0001769029,0.00004047667,0.000002110942,0.00006396475,0.00000557759,0.00003709703,0.9984024,0.00007241521,0.0000153985,0.001112544],"study_design_scores_gemma":[0.000009610018,0.00009285831,0.00560606,0.000007059232,0.00001376333,0.001195178,0.0000220954,0.0006710049,0.9883624,0.0001080444,0.00390471,0.00000713761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982724,0.003203532,0.011015,0.0002543232,0.00003190306,0.00004909186,0.00119108,0.000186596,0.001344492],"genre_scores_gemma":[0.987784,0.001814962,0.007016728,0.00006134242,0.000014583,0.00002767581,0.001355127,0.00003333098,0.001892305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007846372,"threshold_uncertainty_score":0.002624869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05012720668685855,"score_gpt":0.3049090385355746,"score_spread":0.2547818318487161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}