{"id":"W4391251789","doi":"10.1016/j.isci.2024.109006","title":"Chemical and biological characterization of vaccine adjuvant QS-21 produced via plant cell culture","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Bill and Melinda Gates Foundation","keywords":"Adjuvant; Immune system; Recombinant DNA; Saponin; Antigen; Vaccine adjuvant; Biology; Chemistry; Computational biology; Immunology; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383198,0.0002244596,0.0001332585,0.0001630424,0.0001333153,0.0001484381,0.0001074925,0.0001633536,0.000681412],"category_scores_gemma":[0.0001616054,0.00005171441,0.0001304742,0.0002441248,0.0001235974,0.0001450755,0.00008459288,0.0003939573,0.0003946424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001457265,"about_ca_system_score_gemma":0.0001668958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005856582,"about_ca_topic_score_gemma":0.0006258222,"domain_scores_codex":[0.9999417,0.000008841009,0.000005462664,0.000009273228,0.00002390722,0.00001072553],"domain_scores_gemma":[0.9999081,0.00002672392,0.00001812684,0.00001122277,0.00002375982,0.00001216172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008245119,0.000008460133,0.00003368132,0.00001221734,6.013152e-7,0.00001276283,0.000005599064,0.0000591359,0.9995649,0.00002450183,0.000006425422,0.0002634459],"study_design_scores_gemma":[0.00000336819,0.0001562128,0.001269878,0.000003692621,0.000007332637,0.00003841617,0.00001483757,0.0004048915,0.9957787,0.00003647,0.002282948,0.000003277526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809599,0.001940535,0.01188002,0.00009608337,0.0000369719,0.0001390085,0.001625959,0.0000514866,0.003270118],"genre_scores_gemma":[0.983114,0.001884803,0.007765708,0.00008004085,0.00001786305,0.00009733667,0.003333003,0.00002802382,0.003679232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000681412,"threshold_uncertainty_score":0.00227952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00885401380210742,"score_gpt":0.2281586466224002,"score_spread":0.2193046328202927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}