{"id":"W4391253295","doi":"10.1007/s12031-023-02177-0","title":"Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin","year":2024,"lang":"en","type":"article","venue":"Journal of Molecular Neuroscience","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Manitoba","funders":"Ontario Rett Syndrome Association; University of Manitoba","keywords":"MECP2; Gene isoform; Biology; Transcription factor; Molecular biology; Flow cytometry; Epigenetics; DNA methylation; Cell biology; Gene expression; Gene; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002355359,0.0001831802,0.0001593902,0.00006593258,0.0001011745,0.00007470663,0.0002357073,0.00008620947,0.00000488316],"category_scores_gemma":[0.00005420234,0.000129089,0.0001272368,0.0002156847,0.0002870492,0.00002700834,0.00008675087,0.0001810427,1.73454e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001878702,"about_ca_system_score_gemma":0.0001919482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005813809,"about_ca_topic_score_gemma":0.000005445903,"domain_scores_codex":[0.998584,0.00008118388,0.0003229915,0.0003086868,0.0004922001,0.0002109612],"domain_scores_gemma":[0.999473,0.000008834621,0.0001701111,0.0001500604,0.0000925973,0.0001053966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002788359,0.00005315152,0.00007397404,0.00002549146,0.00001687084,0.000008047043,0.0001279941,0.0001082462,0.9973892,0.00004517446,0.001563119,0.0005608387],"study_design_scores_gemma":[0.0003631232,0.0003249188,0.003684615,0.0000498585,0.0000272345,0.0001665147,0.00005107035,0.0006195282,0.9916174,0.0003125176,0.002636949,0.000146299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945027,0.001522626,0.002005229,0.00139269,0.0002652779,0.0001788864,0.00008536431,0.000004269025,0.00004290832],"genre_scores_gemma":[0.9982336,0.0003614884,0.0001836065,0.0009894503,0.000007230952,0.000004041299,0.00001066063,0.00002146936,0.0001884707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005771839,"threshold_uncertainty_score":0.5264096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009290741609336411,"score_gpt":0.2201420890941245,"score_spread":0.2108513474847881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}