{"id":"W4391256719","doi":"10.1016/j.isci.2024.109018","title":"In vitro and in vivo models define a molecular signature reference for human embryonic notochordal cells","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dutch Arthritis Association; ReumaNederland; Centre National de la Recherche Scientifique; Innovation and Technology Commission; Institut National de la Santé et de la Recherche Médicale; European Commission; Université de Nantes; Arthritis Society; Agence Nationale de la Recherche; Dutch Arthritis Society; Infrastructures en Biologie Santé et Agronomie","keywords":"Embryonic stem cell; Signature (topology); Computational biology; In vitro; Regenerative medicine; Cell biology; Biology; In vivo; Chemistry; Stem cell; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170657,0.00008311209,0.0000714685,0.00006567994,0.00003523085,0.00002036376,0.0001037776,0.0001221065,0.000003060177],"category_scores_gemma":[0.000008315077,0.00007549781,0.00001858437,0.0001354737,0.00008087489,0.00001059331,0.0000620386,0.00006824071,0.000001158229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001429368,"about_ca_system_score_gemma":0.00005550023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008602234,"about_ca_topic_score_gemma":0.00007476472,"domain_scores_codex":[0.9993106,0.00001754812,0.00009964553,0.0003499438,0.00005151584,0.0001707853],"domain_scores_gemma":[0.9998466,0.000008462508,0.00001429278,0.00009071389,0.00001322338,0.00002672472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003333113,0.00001060479,0.00003303353,0.00001660593,0.000002072164,0.00000515775,0.00003550936,0.0003168145,0.9978763,0.0006418953,0.0001058036,0.0009228065],"study_design_scores_gemma":[0.0001840757,0.00005991017,0.0003392615,0.00001955458,0.000001821387,0.000006619476,0.00001131152,0.00239292,0.9906362,0.003800112,0.002435102,0.0001130924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942686,0.002297733,0.002541478,0.0001908109,0.00007586022,0.000221489,0.00001745996,0.000005416139,0.0003811345],"genre_scores_gemma":[0.9978755,0.00004479219,0.001278059,0.0001655391,0.00001526205,0.00004698619,0.00002483308,0.000005159694,0.0005438303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007240146,"threshold_uncertainty_score":0.3078711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107168487510685,"score_gpt":0.2648311083362898,"score_spread":0.2537594234611829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}