{"id":"W4391256719","doi":"10.1016/j.isci.2024.109018","title":"In vitro and in vivo models define a molecular signature reference for human embryonic notochordal cells","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dutch Arthritis Association; ReumaNederland; Centre National de la Recherche Scientifique; Innovation and Technology Commission; Institut National de la Santé et de la Recherche Médicale; European Commission; Université de Nantes; Arthritis Society; Agence Nationale de la Recherche; Dutch Arthritis Society; Infrastructures en Biologie Santé et Agronomie","keywords":"Embryonic stem cell; Signature (topology); Computational biology; In vitro; Regenerative medicine; Cell biology; Biology; In vivo; Chemistry; Stem cell; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003196714,0.0004018252,0.00027656,0.0006780127,0.0003429693,0.0005498844,0.000248916,0.0003519783,0.00140479],"category_scores_gemma":[0.0002966076,0.0001570668,0.000198962,0.000442682,0.0003348524,0.0003607282,0.0003998318,0.0004649012,0.0005994415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000317202,"about_ca_system_score_gemma":0.0005184191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009798952,"about_ca_topic_score_gemma":0.001854731,"domain_scores_codex":[0.9997686,0.00003420682,0.00002951279,0.00006743836,0.00007650621,0.00002367853],"domain_scores_gemma":[0.999799,0.00003831237,0.00004251516,0.00005004162,0.00004796986,0.0000222893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000272178,0.000005671018,0.000487267,0.00003971297,0.000002427347,0.00004400128,0.00002369197,0.0001081321,0.9954416,0.0004329922,0.00004847195,0.003338947],"study_design_scores_gemma":[0.000004100656,0.0001767134,0.01768072,0.00003195589,0.00003646926,0.000745645,0.0001450227,0.001551017,0.9577909,0.00063069,0.02119472,0.00001219185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7172655,0.009256138,0.2454104,0.0004397201,0.000230983,0.0003904732,0.009386002,0.001035131,0.01658581],"genre_scores_gemma":[0.8514173,0.006827951,0.1207773,0.0002170118,0.00006662582,0.0004515329,0.011119,0.0002616554,0.008861557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00140479,"threshold_uncertainty_score":0.004699469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107168487510685,"score_gpt":0.2648311083362898,"score_spread":0.2537594234611829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}