{"id":"W4391262451","doi":"10.7554/elife.89371.2","title":"DNA methylation-environment interactions in the human genome","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institutes of Health","keywords":"DNA methylation; Enhancer; Methylation; CpG site; Biology; Bisulfite sequencing; Epigenetics; Epigenomics; Differentially methylated regions; Gene; Genetics; Illumina Methylation Assay; Human genome; Genome; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000321603,0.0002109426,0.000297802,0.0003750785,0.0001731121,0.0002807535,0.000139111,0.0002647467,0.00252151],"category_scores_gemma":[0.0006119886,0.0002600731,0.0003286974,0.0004561169,0.0001654151,0.000144757,0.0004496321,0.0004087783,0.0005984192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122202,"about_ca_system_score_gemma":0.0002088905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001935145,"about_ca_topic_score_gemma":0.003312228,"domain_scores_codex":[0.999724,0.00003516241,0.000007983985,0.0001432654,0.00006165395,0.00002794781],"domain_scores_gemma":[0.9998635,0.00005871305,0.00003127482,0.00001958594,0.00001461258,0.00001231942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006394056,0.00002314432,0.04426493,0.0002695673,0.0003571255,0.0001751848,0.000165473,0.005282444,0.8924368,0.001952335,0.001847264,0.05258631],"study_design_scores_gemma":[0.00004498937,0.0003346011,0.6045963,0.000053154,0.0003041786,0.001095175,0.0001657459,0.01916864,0.3283404,0.008755795,0.03707778,0.000063304],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.905777,0.006309652,0.06144077,0.0008598907,0.0001112692,0.00003701961,0.01763584,0.001351978,0.006476602],"genre_scores_gemma":[0.9653714,0.001265282,0.02156419,0.0003726206,0.00004151926,0.00003445822,0.008066701,0.0001335531,0.003150256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00252151,"threshold_uncertainty_score":0.008435309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813897384707498,"score_gpt":0.3145729272989269,"score_spread":0.2864339534518519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}