{"id":"W4391263782","doi":"","title":"Spesolimab, A Novel Interleukin-36 Inhibitor for Generalized Pustular Psoriasis Flares in Adult Patients.","year":2024,"lang":"en","type":"article","venue":"PubMed","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; Probity Medical Research; Health Sciences Centre; University of Toronto; Women's College Hospital; McMaster University; Dermatrials Research; University of Calgary; Sunnybrook Health Science Centre; Western University","funders":"","keywords":"Generalized pustular psoriasis; Psoriasis; Medicine; Interleukin 1 receptor antagonist; Pathogenesis; Interleukin; Immunology; Disease; Dermatology; Clinical trial; Receptor antagonist; Immune system; Antagonist; Receptor; Internal medicine; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271137,0.0003248013,0.0004400504,0.0004551196,0.0001429858,0.0002974447,0.0001734345,0.0004284291,0.00112007],"category_scores_gemma":[0.0001821247,0.00007525194,0.0003694894,0.0002701243,0.000106723,0.0003081165,0.0001483948,0.0006687776,0.0006443667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265088,"about_ca_system_score_gemma":0.0002654309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000228918,"about_ca_topic_score_gemma":0.0008202595,"domain_scores_codex":[0.9998947,0.00002504626,0.00001769213,0.00001226513,0.00003106365,0.00001914612],"domain_scores_gemma":[0.9999461,0.00001156383,0.00001650662,0.000001446075,0.00001189134,0.00001245964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000868912,0.0001684625,0.0007686,0.005265219,0.0001658572,0.001743587,0.00008180444,0.0003117016,0.02586064,0.001198088,0.03594319,0.9276239],"study_design_scores_gemma":[0.001313801,0.00384557,0.006594316,0.001047564,0.0003455107,0.02221183,0.00007758371,0.0004643335,0.01166407,0.0009684364,0.9514282,0.0000388297],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01032437,0.9808096,0.0009930833,0.001525382,0.0005359526,0.0000643784,0.0001410925,0.00008654804,0.005519558],"genre_scores_gemma":[0.1290083,0.848564,0.003390657,0.005865008,0.001616567,0.0001567758,0.001238056,0.00002724341,0.0101334],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00112007,"threshold_uncertainty_score":0.003746986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915470647615576,"score_gpt":0.2249124229588418,"score_spread":0.2057577164826861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}