{"id":"W4391270041","doi":"10.1021/acsnano.3c09491","title":"Synergistic Viro-chemoimmunotherapy in Breast Cancer Enabled by Bioengineered Immunostimulatory Exosomes and Dual-Targeted Coxsackievirus B3","year":2024,"lang":"en","type":"article","venue":"ACS Nano","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Cancer Society","keywords":"Oncolytic virus; Immune system; Microvesicles; Tumor microenvironment; Cancer research; Exosome; Cancer cell; Immunotherapy; Breast cancer; Cancer immunotherapy; Cancer; Medicine; Immunology; Biology; microRNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483556,0.000255595,0.0001626374,0.0002258188,0.00009733485,0.0002382739,0.0001240117,0.0002668788,0.0007802396],"category_scores_gemma":[0.00005691101,0.0001450912,0.0002465991,0.0001566671,0.0001444479,0.0002036424,0.0001964033,0.0002815816,0.0002206482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329166,"about_ca_system_score_gemma":0.0002081219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005050848,"about_ca_topic_score_gemma":0.0007357243,"domain_scores_codex":[0.9999155,0.000009330698,0.000004646183,0.00002024197,0.00002746255,0.00002283423],"domain_scores_gemma":[0.999977,0.000003918347,0.000006407078,0.000002926417,0.000004489768,0.000005240358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005933971,0.00001645323,0.00006675523,0.00003178832,0.000003835261,0.00003649711,0.00001287871,0.0001515008,0.9968649,0.0001251731,0.00007884404,0.002552135],"study_design_scores_gemma":[0.000007725047,0.00008330045,0.0007715314,0.0000026391,0.000006469802,0.00007896632,0.000009977467,0.00185372,0.9958196,0.00002809009,0.001334012,0.000003898207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827642,0.002689912,0.01025705,0.0001353425,0.00005967135,0.0000507451,0.0002403976,0.0002979968,0.00350477],"genre_scores_gemma":[0.9877467,0.001263445,0.007879089,0.00006017187,0.000007177355,0.00006645838,0.0001522383,0.00004099673,0.00278371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007802396,"threshold_uncertainty_score":0.002610087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006898337878550874,"score_gpt":0.2657237151696643,"score_spread":0.2588253772911134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}