{"id":"W4391270041","doi":"10.1021/acsnano.3c09491","title":"Synergistic Viro-chemoimmunotherapy in Breast Cancer Enabled by Bioengineered Immunostimulatory Exosomes and Dual-Targeted Coxsackievirus B3","year":2024,"lang":"en","type":"article","venue":"ACS Nano","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Cancer Society","keywords":"Oncolytic virus; Immune system; Microvesicles; Tumor microenvironment; Cancer research; Exosome; Cancer cell; Immunotherapy; Breast cancer; Cancer immunotherapy; Cancer; Medicine; Immunology; Biology; microRNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002508451,0.0002823469,0.0002482816,0.0001512582,0.00006887803,0.00008463262,0.0002084993,0.0002207985,0.0001767215],"category_scores_gemma":[0.00002405969,0.0002664007,0.00006848104,0.0003130137,0.000142641,0.00001219443,0.0000913007,0.0001929521,0.00002679866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007260747,"about_ca_system_score_gemma":0.0002002396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002500215,"about_ca_topic_score_gemma":0.00005747473,"domain_scores_codex":[0.9984459,0.00009322969,0.0002709032,0.0005286084,0.0001975469,0.0004638237],"domain_scores_gemma":[0.9993476,0.00003950312,0.00003344731,0.0004288625,0.00005870139,0.00009185349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00075694,0.00006088337,0.0004513382,0.00005731162,0.000190613,0.0000242896,0.00006003197,0.0001026814,0.9855209,0.00001014764,0.002911073,0.009853793],"study_design_scores_gemma":[0.001520241,0.0004568273,0.002444061,0.00009854526,0.00002021577,0.00002131483,0.0000250321,0.0005142852,0.9805124,0.00002991056,0.01393018,0.0004269835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9097413,0.08892239,0.00002298294,0.0005261881,0.0001845491,0.0002560535,0.0002454033,0.00004554235,0.00005554195],"genre_scores_gemma":[0.9858679,0.01207647,0.00001989289,0.0003110841,0.0001216832,0.00009237128,0.0001640668,0.0000835137,0.001263046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07684592,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006898337878550874,"score_gpt":0.2657237151696643,"score_spread":0.2588253772911134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}