{"id":"W4391270302","doi":"10.1101/2024.01.25.577241","title":"Variability in HIV-1 Transmitted/Founder Virus Susceptibility to Combined APOBEC3F and APOBEC3G Host Restriction","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"APOBEC3G; Biology; Cytosine deaminase; Virology; Infectivity; Cytidine deaminase; Enzyme; Human immunodeficiency virus (HIV); DNA; Virus; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00021851,0.0001511924,0.000162949,0.0004066365,0.0001241704,0.0002816976,0.0001361553,0.0002357448,0.001550214],"category_scores_gemma":[0.0003782284,0.00006213173,0.0001477088,0.000185911,0.0001119068,0.0000920081,0.0001374792,0.0002746706,0.0002031622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001537208,"about_ca_system_score_gemma":0.00006008574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005392414,"about_ca_topic_score_gemma":0.0005183069,"domain_scores_codex":[0.9997576,0.00004578733,0.0000212247,0.0000765312,0.00005610473,0.00004273559],"domain_scores_gemma":[0.9997469,0.00006567788,0.00005772652,0.000037763,0.00003186776,0.00006016507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002404082,0.00007786072,0.03712383,0.0000174076,0.00006611345,0.0001348833,0.0001372726,0.000113561,0.9586721,0.0001235243,0.00005730084,0.003235638],"study_design_scores_gemma":[0.00003893505,0.001568913,0.7847415,0.00002086433,0.0001422735,0.007608136,0.0003924903,0.003143107,0.1994808,0.000243351,0.002591131,0.00002852567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994695,0.00009045535,0.0001465683,0.000004101717,0.000001381648,0.000003372861,0.00009165717,0.000003763445,0.0001891843],"genre_scores_gemma":[0.9994624,0.00002856252,0.0001103632,0.000004232807,0.000001681311,0.000003378291,0.0001537407,0.000003224406,0.0002323385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001550214,"threshold_uncertainty_score":0.005186021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315840733079522,"score_gpt":0.2389595106289352,"score_spread":0.22580110329814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}