{"id":"W4391289721","doi":"10.1016/j.jaci.2024.01.013","title":"Allogeneic hematopoietic cell transplantation is effective for p47phox chronic granulomatous disease: A  Primary Immune Deficiency Treatment Consortium study","year":2024,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Montreal Clinical Research Institute; Alberta Children's Hospital; SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Canadian Institutes of Health Research; National Center for Advancing Translational Sciences; Health Resources and Services Administration; National Cancer Institute; University of Toronto; National Heart, Lung, and Blood Institute; Hospital for Sick Children; NHLBI Division of Intramural Research; Pediatric Blood and Marrow Transplant Consortium; CSL Behring; St. Baldrick's Foundation; Vaccine Research Center; California Institute of Regenerative Medicine; California Institute for Regenerative Medicine; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Chronic granulomatous disease; Medicine; Hematopoietic stem cell transplantation; Primary immunodeficiency; Cumulative incidence; Transplantation; Immunology; Inflammatory bowel disease; Internal medicine; Gastroenterology; Incidence (geometry); Immune system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006752685,0.000289165,0.0006806523,0.0002341474,0.0005037145,0.0004554279,0.0003116018,0.0003652871,0.00248757],"category_scores_gemma":[0.000436355,0.00007224773,0.0005243294,0.0002675193,0.0005228943,0.0002801268,0.0002164392,0.0006473899,0.000205985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003322024,"about_ca_system_score_gemma":0.0008157919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008276752,"about_ca_topic_score_gemma":0.001360305,"domain_scores_codex":[0.9997231,0.0001286427,0.0000163346,0.00003321395,0.0000408845,0.00005780106],"domain_scores_gemma":[0.9996706,0.00006534202,0.00005431497,0.00003674882,0.00002406916,0.0001488721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2211209,0.1002932,0.05820297,0.0008811192,0.001291333,0.004470723,0.0007006933,0.001523231,0.1835517,0.002002027,0.004560377,0.4214017],"study_design_scores_gemma":[0.08381546,0.4998879,0.3437857,0.0002489992,0.002293948,0.008140566,0.001173801,0.002199634,0.0421492,0.0007848099,0.01543916,0.00008085646],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976757,0.0007604551,0.0001537113,0.0001864412,0.00002111091,0.0001083421,0.00009079574,0.000008438218,0.0009948437],"genre_scores_gemma":[0.9986181,0.0005496711,0.000164619,0.0001036601,0.00003973531,0.00004369209,0.0001081086,0.000003060942,0.0003693303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00248757,"threshold_uncertainty_score":0.008321762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435282047964497,"score_gpt":0.2910792276418496,"score_spread":0.2767264071622046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}