{"id":"W4391296611","doi":"10.1007/s00213-024-06534-8","title":"Acute, but not repeated, cocaine exposure alters allopregnanolone levels in the midbrain of male and female rats","year":2024,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Foundation of Hope for Research and Treatment of Mental Illness; University of North Carolina at Chapel Hill; National Institutes of Health; Center for Alcohol Studies; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Allopregnanolone; Midbrain; Internal medicine; Medicine; Endocrinology; Psychology; Neuroactive steroid; Pharmacology; Anesthesia; Central nervous system; Receptor; GABAA receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007835984,0.0005946105,0.0006006623,0.0008622323,0.0004247346,0.000533313,0.000336777,0.0004861222,0.003607435],"category_scores_gemma":[0.0002110719,0.0004305237,0.0002742206,0.0002001554,0.001024844,0.0005941443,0.0003723115,0.001359344,0.0004301069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006734633,"about_ca_system_score_gemma":0.0004516765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003480656,"about_ca_topic_score_gemma":0.009038075,"domain_scores_codex":[0.9997867,0.00001368966,0.000007634516,0.0000683476,0.00005705311,0.00006657766],"domain_scores_gemma":[0.9996338,0.00002397176,0.0001035387,0.00003017983,0.00003861988,0.0001699293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003915403,0.0002587113,0.003092853,0.00003333214,0.00003494375,0.0001917031,0.0001385509,0.00002683579,0.9882197,0.0001385697,0.0001409984,0.003808407],"study_design_scores_gemma":[0.0001493134,0.00334281,0.2381946,0.00002643115,0.0001458268,0.0007270479,0.0008733703,0.0008490217,0.7531071,0.0004263865,0.002098633,0.00005943209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980451,0.000323472,0.0003330934,0.0001448472,0.00003947323,0.000008468919,0.0004420849,0.00003037074,0.0006330512],"genre_scores_gemma":[0.9854688,0.0007106555,0.0009984358,0.0001897346,0.00003063519,0.00007254993,0.0006678194,0.00009693154,0.01176433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003607435,"threshold_uncertainty_score":0.01206803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07338894060860816,"score_gpt":0.3874286156982658,"score_spread":0.3140396750896576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}