{"id":"W4391305542","doi":"10.2139/ssrn.4706360","title":"Standard or High Dose Chemoradiotherapy, with or Without the Protease Inhibitor Nelfinavir, for the Treatment of Locally Advanced Pancreatic Cancer: Efficacy, Safety and Health-Related Quality of Life Outcomes from the Multi-Centre Two Stage Phase 1/Randomised Phase 2 SCALOP-2 Study","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre","funders":"","keywords":"Nelfinavir; Medicine; Pancreatic cancer; Chemoradiotherapy; Quality of life (healthcare); Oncology; Protease inhibitor (pharmacology); Cancer; Internal medicine; Nursing; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001623092,0.0007233808,0.002050206,0.000353684,0.0002051099,0.0008067536,0.0006795928,0.0007929059,0.002939975],"category_scores_gemma":[0.001107662,0.0003165944,0.001768169,0.0005127955,0.0008521906,0.0007935722,0.0003707908,0.001930164,0.0004108303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007623284,"about_ca_system_score_gemma":0.0007370941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007748326,"about_ca_topic_score_gemma":0.00220998,"domain_scores_codex":[0.9993457,0.0003781999,0.00003643542,0.00009526441,0.00006719566,0.0000771691],"domain_scores_gemma":[0.999432,0.0001696427,0.0001383081,0.00008260081,0.00003126535,0.0001461846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9385642,0.005527081,0.002675946,0.0007610319,0.002631383,0.00003430982,0.0000513433,0.0008242489,0.005611257,0.00009546989,0.0008329658,0.04239062],"study_design_scores_gemma":[0.801919,0.1700535,0.02115475,0.00009697075,0.002565925,0.0001158922,0.00005283695,0.0005802519,0.001508936,0.000293804,0.001621818,0.00003651116],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918148,0.00519753,0.0003302261,0.0002487707,0.0001056183,0.0004297208,0.0007882848,0.00004122207,0.001043902],"genre_scores_gemma":[0.9928946,0.002861243,0.000827824,0.0005052548,0.0001219349,0.0004419954,0.001316511,0.00001804872,0.001012609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002939975,"threshold_uncertainty_score":0.009835184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06789085269377507,"score_gpt":0.4390783109616215,"score_spread":0.3711874582678465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}