{"id":"W4391318137","doi":"10.1152/ajpcell.00537.2023","title":"Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy","year":2024,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cachexia; Chemotherapy; Myogenesis; Wasting; Muscle atrophy; Myosin; mTORC1; Anabolism; Endocrinology; Internal medicine; Pharmacology; Chemistry; Cancer research; Biochemistry; Medicine; Phosphorylation; Cancer; Skeletal muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777992,0.0002926432,0.0006653721,0.0002142063,0.0002622546,0.0004844996,0.0004062788,0.0003571362,0.00162719],"category_scores_gemma":[0.0002017274,0.0001106487,0.0002293757,0.0001842186,0.0004044396,0.0003346539,0.0002549325,0.001227472,0.0004634687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003775447,"about_ca_system_score_gemma":0.0004342243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007538365,"about_ca_topic_score_gemma":0.001970954,"domain_scores_codex":[0.9998465,0.00002546899,0.00001425161,0.00002161845,0.00003804668,0.00005411923],"domain_scores_gemma":[0.9998338,0.00002072811,0.00004723695,0.00001932043,0.00002739672,0.00005151373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001299317,0.0003483338,0.0004856088,0.000166869,0.00003279505,0.0000582006,0.00004053965,0.0001178591,0.9888038,0.0001717288,0.0003787593,0.008096205],"study_design_scores_gemma":[0.0003840766,0.006862114,0.009850573,0.0000374435,0.0001489851,0.0002684662,0.0001765635,0.001937503,0.9695534,0.0001715544,0.01058902,0.00002028034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928545,0.003701547,0.001281544,0.0005915707,0.0001325693,0.00005151971,0.0001949218,0.0002079014,0.0009839017],"genre_scores_gemma":[0.9947165,0.001437978,0.0008351596,0.0001564537,0.000029634,0.00007523077,0.0003464079,0.00003588434,0.002366831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00162719,"threshold_uncertainty_score":0.005443454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003134155906780303,"score_gpt":0.2162988239613909,"score_spread":0.2131646680546106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}