{"id":"W4391324083","doi":"10.3390/antiox13020171","title":"Antioxidative Sirt1 and the Keap1-Nrf2 Signaling Pathway Impair Inflammation and Positively Regulate Autophagy in Murine Mammary Epithelial Cells or Mammary Glands Infected with Streptococcus uberis","year":2024,"lang":"en","type":"article","venue":"Antioxidants","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Streptococcus uberis; Oxidative stress; Autophagy; Biology; Inflammation; Reactive oxygen species; Superoxide dismutase; Immunology; Endocrinology; Cell biology; Biochemistry; Streptococcus; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000303215,0.0004641495,0.0004575137,0.0003370556,0.0001889152,0.0002436355,0.0002045633,0.0003824324,0.001878579],"category_scores_gemma":[0.0001083412,0.0002162861,0.0004837501,0.0002289773,0.0003078775,0.0002736168,0.0002056683,0.0006470482,0.0002627193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002920495,"about_ca_system_score_gemma":0.000300926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006922391,"about_ca_topic_score_gemma":0.001077455,"domain_scores_codex":[0.9997059,0.00005283374,0.00003709569,0.00005498452,0.00005690005,0.00009234187],"domain_scores_gemma":[0.9999036,0.000009596613,0.00003199823,0.00001207321,0.000011465,0.00003137119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006974099,0.00008664592,0.0003859511,0.0001163702,0.00001309683,0.0000481537,0.00002967298,0.00003756754,0.9974571,0.00006621217,0.00007144837,0.0009904269],"study_design_scores_gemma":[0.00005074732,0.0009936861,0.01290399,0.0000197711,0.00004837371,0.0002426756,0.0001218914,0.0009818451,0.9821979,0.0001087645,0.002322383,0.000007996248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992262,0.003947511,0.001603762,0.0002421433,0.00008007628,0.00003507279,0.0008697368,0.00009008766,0.0008695279],"genre_scores_gemma":[0.992855,0.001614306,0.00131065,0.0001257542,0.00001618624,0.00008138156,0.0009142251,0.000008974071,0.003073487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878579,"threshold_uncertainty_score":0.006284535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006921156681341576,"score_gpt":0.2411351712918494,"score_spread":0.2342140146105079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}