{"id":"W4391325299","doi":"10.1177/17588359231220511","title":"The role of aberrant DNA methylation in cancer initiation and clinical impacts","year":2024,"lang":"en","type":"article","venue":"Therapeutic Advances in Medical Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; National Cancer Institute; National Institutes of Health; Sierra Oncology; Swiss Cancer Research Foundation; Eisai; BeiGene; Clovis Oncology; AstraZeneca","keywords":"DNA methylation; Epigenetics; Methylation; Cancer research; DNA repair; Biology; Cancer epigenetics; MSH2; Context (archaeology); MLH1; DNA mismatch repair; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007478601,0.0002577109,0.0005832827,0.0007739065,0.0002783702,0.001004589,0.0003125562,0.0007118213,0.001394696],"category_scores_gemma":[0.001160607,0.0001674353,0.000303677,0.0006704118,0.0008066857,0.000714189,0.0005713296,0.001122293,0.000457571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008163564,"about_ca_system_score_gemma":0.0008041629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035328,"about_ca_topic_score_gemma":0.001073851,"domain_scores_codex":[0.9996454,0.0001045838,0.00003738038,0.00007650874,0.00009164427,0.00004452648],"domain_scores_gemma":[0.9995728,0.0002357201,0.00007455951,0.00001836469,0.00006828405,0.0000301925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005300913,0.00007315013,0.02119835,0.009212147,0.0002673527,0.002930577,0.001162107,0.00301816,0.1003188,0.04766342,0.01107949,0.8025464],"study_design_scores_gemma":[0.00002704059,0.0006024005,0.06745246,0.003299422,0.0003785794,0.01508598,0.0008288056,0.001579757,0.06188428,0.04485445,0.8038666,0.00014019],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01727188,0.9659602,0.004688113,0.004040467,0.0004665978,0.00002008117,0.0002558696,0.0000552803,0.00724161],"genre_scores_gemma":[0.1385704,0.8538586,0.002754685,0.0008748315,0.0007082919,0.00003358363,0.0001866518,0.00001634908,0.002996595],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001394696,"threshold_uncertainty_score":0.005923152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222546235469653,"score_gpt":0.4208826697653826,"score_spread":0.3986572074106861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}