{"id":"W4391325299","doi":"10.1177/17588359231220511","title":"The role of aberrant DNA methylation in cancer initiation and clinical impacts","year":2024,"lang":"en","type":"article","venue":"Therapeutic Advances in Medical Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; National Cancer Institute; National Institutes of Health; Sierra Oncology; Swiss Cancer Research Foundation; Eisai; BeiGene; Clovis Oncology; AstraZeneca","keywords":"DNA methylation; Epigenetics; Methylation; Cancer research; DNA repair; Biology; Cancer epigenetics; MSH2; Context (archaeology); MLH1; DNA mismatch repair; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001486263,0.00007547583,0.0001618246,0.00004694037,0.00002298306,0.000006422415,0.00009474305,0.0002315084,0.00001756675],"category_scores_gemma":[0.0002669432,0.0000523286,0.00003332395,0.0001241611,0.0002287885,0.000008047384,0.00003867869,0.0001939035,7.439018e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003262118,"about_ca_system_score_gemma":0.000235387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002731577,"about_ca_topic_score_gemma":0.001575747,"domain_scores_codex":[0.9987696,0.0003058417,0.0004293524,0.0001940462,0.0001492898,0.0001518172],"domain_scores_gemma":[0.9992759,0.0004654721,0.00007810289,0.0001002017,0.00002838819,0.00005197326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001071726,0.00005590393,0.01456862,0.00001508294,0.0000194322,0.000002876007,0.0001147699,0.00004026542,0.02078411,0.00106473,0.000001583538,0.9632254],"study_design_scores_gemma":[0.002466133,0.002135672,0.1439239,0.0002465039,0.00006813018,0.000009493879,0.0005324536,0.01646689,0.0686502,0.07818844,0.6869758,0.0003364362],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7516824,0.2448303,0.00111002,0.0009113938,0.0003779659,0.0001379468,0.000002208947,0.000004228469,0.0009435251],"genre_scores_gemma":[0.8579026,0.1416942,0.00009202648,0.0001261783,0.0001401881,0.00002020356,0.000007828952,0.000007327902,0.0000094146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.962889,"threshold_uncertainty_score":0.2133898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222546235469653,"score_gpt":0.4208826697653826,"score_spread":0.3986572074106861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}