{"id":"W4391328111","doi":"10.20944/preprints202401.1974.v1","title":"Transforming Growth Factor Beta and Alveolar Rhabdomyosarcoma: A Challenge of Tumor Differentiation and Chemotherapy Response","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; McGill University; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"BETA (programming language); Alveolar rhabdomyosarcoma; Chemotherapy; Rhabdomyosarcoma; Cancer research; Transforming growth factor beta; Medicine; Oncology; Internal medicine; Transforming growth factor; Pathology; Sarcoma; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003941163,0.0004357176,0.0008306077,0.0002864262,0.0000544187,0.00002138633,0.0001196887,0.0002514044,0.0001860487],"category_scores_gemma":[0.00009029074,0.0003702721,0.0002533312,0.00008775754,0.0001197845,0.00004935617,0.0004816357,0.0005890688,0.00002543888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001147975,"about_ca_system_score_gemma":0.0001201918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001398704,"about_ca_topic_score_gemma":0.0000119807,"domain_scores_codex":[0.9978424,0.0001309458,0.0005333837,0.0008909659,0.0003387561,0.0002635726],"domain_scores_gemma":[0.998697,0.0002262469,0.0001906803,0.0005959321,0.0001025692,0.0001875017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001474801,0.000869102,0.9644795,0.002538894,0.001060005,0.0001262655,0.005573772,2.96376e-7,0.01633917,0.0004820132,0.00000624539,0.007049944],"study_design_scores_gemma":[0.002067719,0.0001522587,0.9158128,0.00110364,0.000517251,0.00004776291,0.0001081265,0.00005889924,0.07764912,0.001938158,0.0002808185,0.0002633876],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870006,0.006154865,0.00001861323,0.004755437,0.0001472116,0.001392106,0.00009026974,0.0001012503,0.0003395899],"genre_scores_gemma":[0.99588,0.003446363,0.0001534942,0.00009767036,0.00007774458,0.0001672378,0.00003247845,0.00007084077,0.00007416082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06130995,"threshold_uncertainty_score":0.9998749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07015150432129677,"score_gpt":0.3294588256234041,"score_spread":0.2593073213021073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}