{"id":"W4391338127","doi":"10.1182/bloodadvances.2023012109","title":"Large B-cell lymphoma-<i>IRF4</i>+ in children and young people: time to reduce chemotherapy in a rare malignant mature B-cell neoplasm?","year":2024,"lang":"en","type":"article","venue":"Blood Advances","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'Adolescent; Japan Agency for Medical Research and Development; Cancer Research Institute","keywords":"IRF4; Neoplasm; Lymphoma; Chemotherapy; B cell; Malignant lymphoma; Cancer research; Medicine; Oncology; Internal medicine; Immunology; Biology; Pathology; Transcription factor; Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293188,0.0002896294,0.0004310374,0.000221238,0.00003646875,0.00006821569,0.00009473568,0.0001149742,0.0001374329],"category_scores_gemma":[0.00001313762,0.0002312385,0.0000765995,0.000540642,0.00002150129,0.0001702856,0.00005499017,0.00009602868,0.0001574535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009171935,"about_ca_system_score_gemma":0.0001190094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001129857,"about_ca_topic_score_gemma":0.0001887462,"domain_scores_codex":[0.9984136,0.0000334141,0.0002877482,0.0006041615,0.0002235269,0.0004375756],"domain_scores_gemma":[0.9994594,0.00006205843,0.00004188829,0.0002531984,0.00001909205,0.0001643306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006311095,0.01355288,0.9077228,0.0009178329,0.0002650624,0.00205966,0.006729542,0.00001589724,0.01354418,0.0001411372,0.007015191,0.04740472],"study_design_scores_gemma":[0.0301882,0.0006382979,0.8642256,0.00143943,0.0002275012,0.001132811,0.0003478011,0.00009560707,0.07708725,0.00007392618,0.02396058,0.0005829458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9541551,0.03934572,0.000001352612,0.001194562,0.0001028003,0.0007834402,0.00008904708,0.00008215057,0.004245764],"genre_scores_gemma":[0.9915959,0.003738592,0.0006797167,0.0005388489,0.0001197839,0.000150991,0.00007580748,0.00004927809,0.003051088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06354308,"threshold_uncertainty_score":0.9429634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002666590924800702,"score_gpt":0.223993790102292,"score_spread":0.2213271991774913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}