{"id":"W4391338127","doi":"10.1182/bloodadvances.2023012109","title":"Large B-cell lymphoma-<i>IRF4</i>+ in children and young people: time to reduce chemotherapy in a rare malignant mature B-cell neoplasm?","year":2024,"lang":"en","type":"article","venue":"Blood Advances","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Société Française de lutte contre les Cancers et les leucémies de l'Enfant et de l'Adolescent; Japan Agency for Medical Research and Development; Cancer Research Institute","keywords":"IRF4; Neoplasm; Lymphoma; Chemotherapy; B cell; Malignant lymphoma; Cancer research; Medicine; Oncology; Internal medicine; Immunology; Biology; Pathology; Transcription factor; Antibody; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000095575,0.0001146206,0.0003375468,0.0001460189,0.0003963039,0.0003001126,0.0001832944,0.0006220245,0.002255976],"category_scores_gemma":[0.000539832,0.00006225028,0.0001646539,0.0001686396,0.0001219104,0.000573779,0.0001370029,0.0006360278,0.0003279243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002471888,"about_ca_system_score_gemma":0.0005139073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00159497,"about_ca_topic_score_gemma":0.002690344,"domain_scores_codex":[0.9999504,0.000009783634,0.00000557022,0.00000853508,0.000008498911,0.00001723253],"domain_scores_gemma":[0.9998935,0.00002003924,0.00002378046,0.000002771427,0.00001133369,0.00004845286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001870076,0.0007943906,0.4273378,0.0009930204,0.0001180778,0.0557912,0.0009045004,0.0005033779,0.005877448,0.002734474,0.04203883,0.4610369],"study_design_scores_gemma":[0.0003578392,0.002473809,0.6450522,0.001972707,0.00048077,0.1674192,0.004895112,0.0009531375,0.003581736,0.006384697,0.1663059,0.0001229436],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7677452,0.1223845,0.002981077,0.07655727,0.002218968,0.0001389115,0.0008921959,0.0002122808,0.02686969],"genre_scores_gemma":[0.9517862,0.03334454,0.00162801,0.007169731,0.001516696,0.00006133213,0.000563696,0.00002486057,0.003905014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002255976,"threshold_uncertainty_score":0.007547021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002666590924800702,"score_gpt":0.223993790102292,"score_spread":0.2213271991774913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}