{"id":"W4391338295","doi":"10.1101/2024.01.27.573841","title":"Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer’s disease in mice","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Sunnybrook Health Science Centre; Ontario Brain Institute; University Health Network; University of Toronto","funders":"Buck Institute for Research on Aging","keywords":"Immune system; Biology; Microglia; Inflammation; Chemokine; Immunology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799765,0.0002851931,0.0003235182,0.000560223,0.0002038983,0.000375737,0.000125174,0.0003439001,0.0009097033],"category_scores_gemma":[0.0001055404,0.0002208389,0.0003752731,0.0002220449,0.0002434057,0.0001711154,0.0001880327,0.0007076882,0.0004371798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002415442,"about_ca_system_score_gemma":0.0001376061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007572153,"about_ca_topic_score_gemma":0.001628735,"domain_scores_codex":[0.9998562,0.000009213173,0.000008165098,0.00005404054,0.00003937834,0.00003296245],"domain_scores_gemma":[0.9998548,0.00001555781,0.00004890626,0.00001164462,0.00003553753,0.00003360797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002116478,0.00001250322,0.001347195,0.00003697741,0.00001697202,0.00006128588,0.00003479352,0.00007214749,0.9969868,0.00004192044,0.00007457549,0.001103197],"study_design_scores_gemma":[0.00005234768,0.0007188715,0.2032713,0.00004830633,0.0001945487,0.001015071,0.0004463168,0.004422828,0.7832911,0.0006028858,0.005889402,0.00004703752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781853,0.00168036,0.009143441,0.0001353471,0.00005719552,0.00005816973,0.009085048,0.0002566461,0.001398524],"genre_scores_gemma":[0.9812166,0.001577603,0.007704852,0.000274045,0.00002673088,0.000177927,0.004685103,0.0001297238,0.004207433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009097033,"threshold_uncertainty_score":0.003043294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02859311764273951,"score_gpt":0.2293510027795718,"score_spread":0.2007578851368323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}