{"id":"W4391349772","doi":"10.1021/acscentsci.3c01105","title":"Ultralow Background Membrane Editors for Spatiotemporal Control of Phosphatidic Acid Metabolism and Signaling","year":2024,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; College of Arts and Sciences, Cornell University; Human Frontier Science Program; National Institutes of Health; Japan Society for the Promotion of Science; Honjo International Scholarship Foundation; Arnold and Mabel Beckman Foundation; Alfred P. Sloan Foundation","keywords":"Phosphatidic acid; Organelle; Phospholipase D; Cell biology; Lipid signaling; Diacylglycerol kinase; Cytosol; Signal transduction; Biochemistry; Biology; Lipid metabolism; Membrane; Chemistry; Enzyme; Phospholipid; Protein kinase C","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007121856,0.0001395316,0.0001916675,0.0001435818,0.0002390213,0.0003341616,0.0004903172,0.00004930436,0.00005213948],"category_scores_gemma":[0.00050767,0.0001138534,0.00006348392,0.0007924323,0.0009762068,0.0006900656,0.00004318616,0.0001289986,0.000005825142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000475603,"about_ca_system_score_gemma":0.0003106171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003830801,"about_ca_topic_score_gemma":0.000001950635,"domain_scores_codex":[0.9976856,0.00004951842,0.0002416362,0.0005538426,0.0007789271,0.0006905372],"domain_scores_gemma":[0.9990171,0.0004040933,0.00005071601,0.0001686181,0.00008861224,0.000270841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003364673,0.00001814352,0.0001546866,0.0000568867,0.000003666026,0.000002749879,0.0002662042,0.00004516133,0.995644,0.001880417,0.00007904531,0.001815344],"study_design_scores_gemma":[0.0003582872,0.00007704415,0.0004540722,0.00002923154,0.00001429406,0.000003524252,0.00004513784,0.008967881,0.9864936,0.0004726331,0.002955146,0.0001291321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897178,0.0009838224,0.005181005,0.0002461324,0.002943147,0.0005612633,0.0001067458,0.00004734853,0.0002127615],"genre_scores_gemma":[0.9984746,0.0001949845,0.0006071727,0.000100412,0.0005497537,0.00002081539,0.000001754151,0.00001336254,0.00003713456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009150433,"threshold_uncertainty_score":0.4642807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03292719248944442,"score_gpt":0.3104913721397791,"score_spread":0.2775641796503346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}