{"id":"W4391349772","doi":"10.1021/acscentsci.3c01105","title":"Ultralow Background Membrane Editors for Spatiotemporal Control of Phosphatidic Acid Metabolism and Signaling","year":2024,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; College of Arts and Sciences, Cornell University; Human Frontier Science Program; National Institutes of Health; Japan Society for the Promotion of Science; Honjo International Scholarship Foundation; Arnold and Mabel Beckman Foundation; Alfred P. Sloan Foundation","keywords":"Phosphatidic acid; Organelle; Phospholipase D; Cell biology; Lipid signaling; Diacylglycerol kinase; Cytosol; Signal transduction; Biochemistry; Biology; Lipid metabolism; Membrane; Chemistry; Enzyme; Phospholipid; Protein kinase C","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802334,0.0003096809,0.000168772,0.0001266795,0.0001664371,0.0004987916,0.0003960816,0.0003540881,0.001511883],"category_scores_gemma":[0.0002412438,0.0001701556,0.0001455004,0.0001189478,0.000326006,0.0005679517,0.0005224613,0.0007294571,0.0004028311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004443967,"about_ca_system_score_gemma":0.0001640513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001688478,"about_ca_topic_score_gemma":0.0003328051,"domain_scores_codex":[0.9998589,0.00001407879,0.000009635626,0.00004696175,0.00004648409,0.00002397344],"domain_scores_gemma":[0.9998429,0.00004218551,0.00005413226,0.0000200045,0.00001432981,0.00002653869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002281994,0.00000537862,0.00003639622,0.00002268171,0.00000169123,0.00002503554,0.00001037851,0.00006815291,0.9972134,0.0007541868,0.00005302441,0.001786836],"study_design_scores_gemma":[0.000004336108,0.00002721049,0.0001385156,0.000002295724,0.000002719195,0.00005787005,0.000007558782,0.000891308,0.9951865,0.0001422549,0.003535327,0.000004050043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8761911,0.002814343,0.1113004,0.0005907423,0.0002718568,0.00009108537,0.000444459,0.0009120428,0.007384047],"genre_scores_gemma":[0.9672033,0.001538358,0.02512642,0.0002217337,0.00004257238,0.00008242214,0.0002229353,0.0001491032,0.005413372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511883,"threshold_uncertainty_score":0.005057693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03292719248944442,"score_gpt":0.3104913721397791,"score_spread":0.2775641796503346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}