{"id":"W4391383725","doi":"10.1038/s41586-023-06878-9","title":"7-Dehydrocholesterol is an endogenous suppressor of ferroptosis","year":2024,"lang":"en","type":"article","venue":"Nature","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":305,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of Mental Health","keywords":"Programmed cell death; Cell biology; Cancer research; Cancer cell; Function (biology); Chemistry; Apoptosis; Endogeny; Biology; Biochemistry; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417291,0.0002437815,0.0002695187,0.0003345263,0.000255164,0.0002575235,0.0002664814,0.0002723096,0.001231876],"category_scores_gemma":[0.000168066,0.000138414,0.0001639036,0.0001465318,0.0003111235,0.0001106466,0.0001630421,0.000381041,0.0003697112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003313225,"about_ca_system_score_gemma":0.0003045924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008791382,"about_ca_topic_score_gemma":0.001305122,"domain_scores_codex":[0.9998875,0.0000172544,0.00001160177,0.00001835716,0.00004164979,0.00002372799],"domain_scores_gemma":[0.9998434,0.00003053476,0.00003413572,0.00001724886,0.00002114851,0.00005370467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002096759,0.00001276304,0.0002226633,0.00001305042,0.000008395807,0.0002827971,0.00000723565,0.0000459139,0.9979882,0.000203521,0.00007051558,0.0009352824],"study_design_scores_gemma":[0.00005487482,0.0002781856,0.003334817,0.000003103044,0.00003476552,0.001823021,0.00002888899,0.0005330469,0.9886017,0.0002001291,0.00509933,0.000008017932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899811,0.00230885,0.003612595,0.0003671101,0.0001515631,0.00002366224,0.0003551116,0.0002275372,0.00297256],"genre_scores_gemma":[0.9960845,0.0004964803,0.0006071887,0.00003537558,0.00002075193,0.000006271142,0.0002936703,0.00002200331,0.002433707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231876,"threshold_uncertainty_score":0.004121065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259347201588815,"score_gpt":0.2675290857805611,"score_spread":0.2549356137646729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}