{"id":"W4391394309","doi":"10.1101/2024.01.30.577659","title":"LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Universidade Federal do Rio de Janeiro; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Universidade Estadual de Campinas; Instituto Serrapilheira; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Instituto D'Or de Pesquisa e Ensino","keywords":"Proteostasis; Cell biology; Neuroplasticity; Organoid; Neurite; Proteomics; Biology; Human brain; Stathmin; Neuroscience; Interactome; Phosphorylation; Biochemistry; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145123,0.0002105793,0.0001849381,0.0002582823,0.0001870001,0.0002382923,0.00007942791,0.0001452023,0.001198947],"category_scores_gemma":[0.00007508807,0.00007995568,0.0002633023,0.000187465,0.0001931051,0.0001072783,0.0002301507,0.0002477485,0.000292574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321959,"about_ca_system_score_gemma":0.0001513562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135387,"about_ca_topic_score_gemma":0.00144429,"domain_scores_codex":[0.9999443,0.000008966283,0.000005857799,0.00001463295,0.00001419303,0.00001201781],"domain_scores_gemma":[0.9999608,0.000009234318,0.00000817832,0.000006552934,0.00000627151,0.000008894032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001665394,0.000007059974,0.0004681741,0.00003451771,0.000009485421,0.00008601283,0.00001998881,0.00004383117,0.9982501,0.00002284442,0.00003825601,0.0008532175],"study_design_scores_gemma":[0.00001314713,0.0001513317,0.02190703,0.000007989748,0.00003155077,0.0004411887,0.0001316292,0.0004493645,0.9742637,0.00004349831,0.002551005,0.000008580663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912642,0.001953218,0.002946161,0.0001255829,0.00002955908,0.00002452044,0.002487635,0.00004965122,0.001119358],"genre_scores_gemma":[0.9905148,0.001525813,0.002787586,0.00005812792,0.000006126024,0.00004865467,0.00258317,0.00001680213,0.002458854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001198947,"threshold_uncertainty_score":0.004010856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718549880622369,"score_gpt":0.2450546409101017,"score_spread":0.227869142103878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}