{"id":"W4391394309","doi":"10.1101/2024.01.30.577659","title":"LSD Modulates Proteins Involved in Cell Proteostasis, Energy Metabolism and Neuroplasticity in Human Cerebral Organoids","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"Universidade Federal do Rio de Janeiro; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Universidade Estadual de Campinas; Instituto Serrapilheira; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Instituto D'Or de Pesquisa e Ensino","keywords":"Proteostasis; Cell biology; Neuroplasticity; Organoid; Neurite; Proteomics; Biology; Human brain; Stathmin; Neuroscience; Interactome; Phosphorylation; Biochemistry; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005778568,0.0008587831,0.001028578,0.000876627,0.0001331798,0.000236416,0.0005136722,0.00075044,0.00006660147],"category_scores_gemma":[0.0000894633,0.0008895161,0.0001289718,0.0009157982,0.0002086353,0.00008303139,0.001390932,0.001582211,0.00003810938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728374,"about_ca_system_score_gemma":0.0002474993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002100352,"about_ca_topic_score_gemma":0.0004025683,"domain_scores_codex":[0.9956726,0.0003587071,0.0009092977,0.001831157,0.0003252725,0.000902937],"domain_scores_gemma":[0.9981415,0.00006729252,0.0002903295,0.00108573,0.0001853488,0.0002297505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002114903,0.001948563,0.09774593,0.002397556,0.000615948,0.0009271756,0.0007465628,0.0001282844,0.8505931,0.04348481,0.001185058,0.00001547992],"study_design_scores_gemma":[0.00321874,0.0001705638,0.79478,0.001048113,0.0002573538,6.040008e-8,0.00006690538,0.0006571321,0.192082,0.0005267957,0.004656427,0.002535978],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987219,0.00893628,0.0000856413,0.0003139236,0.001558347,0.001247473,0.0002160352,0.000282995,0.0001402572],"genre_scores_gemma":[0.997244,0.0002144957,0.0005619561,0.0001779448,0.0004055815,0.0011521,6.277163e-7,0.0002130129,0.00003029447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6970341,"threshold_uncertainty_score":0.9993556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718549880622369,"score_gpt":0.2450546409101017,"score_spread":0.227869142103878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}