{"id":"W4391397897","doi":"10.3389/fddev.2024.1303812","title":"Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts","year":2024,"lang":"en","type":"article","venue":"Frontiers in Drug Delivery","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"SiliCycle (Canada); Université Laval; Centre hospitalier de l'Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Self-healing hydrogels; Polyvinyl alcohol; Chemistry; Viability assay; Cannabinoid; Dermal fibroblast; Fibroblast; Chromatography; Chemical engineering; Biophysics; Polymer chemistry; Cell; Biochemistry; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723054,0.0002499853,0.0001586125,0.0001225854,0.00009267883,0.0002284337,0.0001362926,0.0002103746,0.0005879118],"category_scores_gemma":[0.0001707458,0.0001043954,0.0002221927,0.00009157893,0.0001078196,0.0001736451,0.0001609014,0.0002242555,0.0001920117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001630614,"about_ca_system_score_gemma":0.0001353671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006072252,"about_ca_topic_score_gemma":0.0008397524,"domain_scores_codex":[0.9998938,0.00001608631,0.00001043962,0.00002415744,0.00003360418,0.00002187532],"domain_scores_gemma":[0.9999111,0.00002777643,0.00002407637,0.000009913554,0.00001583295,0.00001128173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003083499,0.00001186034,0.00005994856,0.00004381675,0.00000390036,0.00004754652,0.0000143988,0.00008228373,0.9983453,0.00002264524,0.00001201437,0.001325385],"study_design_scores_gemma":[0.000006462037,0.0001428298,0.0008368337,0.000009589168,0.00001236035,0.0001001763,0.00002106711,0.0005352626,0.9971184,0.00001117323,0.001201219,0.000004787746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893294,0.003639676,0.005195605,0.00007657136,0.00004917791,0.00005831728,0.0001994353,0.00003703536,0.001414827],"genre_scores_gemma":[0.9929669,0.001394679,0.003867758,0.00004142539,0.000009729705,0.00005749931,0.0001238346,0.00001058191,0.001527745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006072252,"threshold_uncertainty_score":0.001966774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024771515668321,"score_gpt":0.2666523741375033,"score_spread":0.25640465898082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}