{"id":"W4391398473","doi":"10.1101/2024.01.30.577847","title":"PREFRONTAL CORRELATES OF FEAR GENERALIZATION DURING ENDOCANNABINOID DEPLETION","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; Vetenskapsrådet; Indivior; BrainsWay; National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression","keywords":"Prefrontal cortex; Fear conditioning; Neuroscience; Psychology; Fear processing in the brain; Amygdala; Extinction (optical mineralogy); Anxiety; Generalization; Endocannabinoid system; Population; Ventromedial prefrontal cortex; Neuroimaging; Medicine; Cognition; Biology; Psychiatry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009098693,0.0001749164,0.0002206598,0.0002522413,0.0001048242,0.0002025585,0.0001053684,0.0001704822,0.0008875309],"category_scores_gemma":[0.0002139785,0.0001128765,0.00009716691,0.000085612,0.0003509674,0.0001268491,0.0002816756,0.0003575999,0.00007374441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002444096,"about_ca_system_score_gemma":0.000121642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00134017,"about_ca_topic_score_gemma":0.002536548,"domain_scores_codex":[0.9999462,0.000005501859,0.000001972936,0.00001807438,0.00001491205,0.00001323897],"domain_scores_gemma":[0.9998752,0.00001085095,0.00006531507,0.00001376566,0.00001112566,0.00002375573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001250528,0.00006214045,0.01580375,0.00003003876,0.00004567892,0.0002199094,0.00008877277,0.0001365897,0.9778249,0.0001136345,0.00008399876,0.004340039],"study_design_scores_gemma":[0.00001598867,0.0002991817,0.9399855,0.000007126409,0.00003006291,0.0007517283,0.0001197579,0.0005071819,0.05769243,0.0003276978,0.0002538256,0.000009588279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988617,0.0001280624,0.0004929513,0.00003794593,0.000002479866,0.000004238997,0.0001466348,0.00001202164,0.0003139664],"genre_scores_gemma":[0.9989184,0.0001329701,0.0002813031,0.00004129881,0.000002664048,0.00001353092,0.0001950251,0.000006425861,0.0004084307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00134017,"threshold_uncertainty_score":0.002969146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032558007538311,"score_gpt":0.2412975925161305,"score_spread":0.2309720124407474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}