{"id":"W4391401389","doi":"10.1021/acs.molpharmaceut.3c01077","title":"Biodistribution of Therapeutic Small Interfering RNAs Delivered with Lipid-Substituted Polyethylenimine-Based Delivery Systems","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; National Institute for Nanotechnology; University of Alberta","funders":"Canadian Institutes of Health Research; Women and Children's Health Research Institute; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Biodistribution; Polyethylenimine; Small interfering RNA; In vivo; Chemistry; RNA interference; Leukemia; Cancer research; Pharmacology; In vitro; Molecular biology; Medicine; Transfection; RNA; Biology; Immunology; Biochemistry; Gene; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195572,0.000253686,0.0001766215,0.0002277632,0.00008235489,0.0002146772,0.0001230281,0.0002685489,0.0003444118],"category_scores_gemma":[0.0001981336,0.0001073104,0.000132658,0.000109758,0.0001728482,0.0002380639,0.0001025273,0.0002637038,0.0001430994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002654552,"about_ca_system_score_gemma":0.000191014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005461611,"about_ca_topic_score_gemma":0.0004068323,"domain_scores_codex":[0.9999074,0.00001990149,0.000009686807,0.00002219494,0.00002545651,0.00001533556],"domain_scores_gemma":[0.9999083,0.00002519979,0.0000301312,0.000006520039,0.00001752404,0.00001226422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000628494,0.000009698911,0.00007164407,0.0000169984,0.000002822625,0.00001589947,0.000009610263,0.00008664875,0.9988756,0.0000282063,0.00000957634,0.00081034],"study_design_scores_gemma":[0.000005988109,0.0003106052,0.0007025721,0.000002144499,0.000009343101,0.00005727051,0.000007066883,0.001124431,0.9974125,0.00001165728,0.0003526934,0.00000366949],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903363,0.00117846,0.007438249,0.0000422972,0.00001354403,0.00003885779,0.00009121237,0.00008272327,0.0007784027],"genre_scores_gemma":[0.9900048,0.0008126818,0.00704996,0.00004530968,0.000005809021,0.00004883504,0.0001899789,0.0000244112,0.001818234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005461611,"threshold_uncertainty_score":0.001926005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422959510966291,"score_gpt":0.2720497568840388,"score_spread":0.2478201617743759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}