{"id":"W4391401389","doi":"10.1021/acs.molpharmaceut.3c01077","title":"Biodistribution of Therapeutic Small Interfering RNAs Delivered with Lipid-Substituted Polyethylenimine-Based Delivery Systems","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; National Institute for Nanotechnology; University of Alberta","funders":"Canadian Institutes of Health Research; Women and Children's Health Research Institute; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Biodistribution; Polyethylenimine; Small interfering RNA; In vivo; Chemistry; RNA interference; Leukemia; Cancer research; Pharmacology; In vitro; Molecular biology; Medicine; Transfection; RNA; Biology; Immunology; Biochemistry; Gene; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001755509,0.0003138891,0.000243555,0.0001396865,0.00005683863,0.00009130739,0.0003119773,0.0001858395,0.00001443618],"category_scores_gemma":[0.00001392303,0.0002809252,0.0001712652,0.0002649301,0.0001448932,0.000009896754,0.00008574002,0.0002041299,0.00001787678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005361543,"about_ca_system_score_gemma":0.000223333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005969695,"about_ca_topic_score_gemma":0.0000136278,"domain_scores_codex":[0.9984818,0.000104619,0.0003609076,0.0004784331,0.0002193813,0.0003548638],"domain_scores_gemma":[0.9991249,0.00002079127,0.00009730749,0.0003986232,0.0002395279,0.0001188782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000334825,0.00007541729,0.0002891001,0.0002199902,0.0004024425,0.00008681392,0.000051492,0.005067209,0.9882233,0.0001164064,0.000114989,0.005018043],"study_design_scores_gemma":[0.0007280622,0.0004069328,0.00006796052,0.0002497696,0.0002311846,0.00005203427,0.00007455142,0.01621958,0.9671637,0.000004894561,0.01445755,0.0003437686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8590486,0.01359142,0.1261935,0.00007945707,0.0004713922,0.0002937442,0.0001237016,0.00005893694,0.0001392149],"genre_scores_gemma":[0.9983134,0.000466494,0.000363047,0.0002267424,0.0001275167,0.00003359767,0.0003479612,0.00005026637,0.00007093267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1392649,"threshold_uncertainty_score":0.9999643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422959510966291,"score_gpt":0.2720497568840388,"score_spread":0.2478201617743759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}