{"id":"W4391403060","doi":"10.1101/2024.01.30.578100","title":"Transcriptome-based screening in TARDBP/TDP-43 knock-in motor neurons identifies the NEDD8-activating enzyme inhibitor MLN4924","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; McGill University Health Centre; Montreal Neurological Institute and Hospital","funders":"Canada First Research Excellence Fund; Québec Consortium for Drug Discovery; McGill University; U.S. Department of Defense","keywords":"TARDBP; Transcriptome; Enzyme; Biology; Cell biology; Genetics; Gene; Gene expression; Biochemistry; SOD1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002027825,0.0005335359,0.0007280087,0.0003991526,0.0001459121,0.0003051755,0.0002035424,0.0002617934,0.001632917],"category_scores_gemma":[0.0001521206,0.0001504701,0.0003519414,0.000256341,0.0001550187,0.0001112913,0.0001469221,0.000379651,0.0005616685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886051,"about_ca_system_score_gemma":0.00021217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006247364,"about_ca_topic_score_gemma":0.001276898,"domain_scores_codex":[0.9998525,0.00001566597,0.0000108125,0.00003421315,0.00006762243,0.00001911056],"domain_scores_gemma":[0.9999264,0.00001603968,0.00002097565,0.000007056967,0.00001567902,0.0000137246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000108278,0.00002361544,0.000179001,0.0000367071,0.000008981036,0.00002435037,0.000003047039,0.0002068582,0.9980806,0.00001573483,0.00005793416,0.001254914],"study_design_scores_gemma":[0.00001751625,0.0004360586,0.003702004,0.0000044668,0.00003083091,0.00008147816,0.000009678479,0.001534254,0.9931362,0.00001849727,0.001023701,0.000005364011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753906,0.001797262,0.007524144,0.0001419539,0.00005038848,0.0001752252,0.01203752,0.0006013996,0.002281613],"genre_scores_gemma":[0.9540234,0.00170671,0.02041226,0.0001623206,0.00001428441,0.0002483712,0.01783172,0.0001686168,0.005432372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001632917,"threshold_uncertainty_score":0.005462706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494056867059862,"score_gpt":0.2367570205656089,"score_spread":0.2218164518950103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}