{"id":"W4391428340","doi":"10.1371/journal.pbio.3002465","title":"Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity","year":2024,"lang":"en","type":"article","venue":"PLoS Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Radboud Universiteit; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"T-cell receptor; Biology; In silico; Antigen; Immunology; Major histocompatibility complex; T cell; Virology; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904315,0.0003228998,0.0004510835,0.0001011119,0.0002306024,0.0005293528,0.0004118082,0.0004178364,0.0015363],"category_scores_gemma":[0.0004221214,0.0001735986,0.0003671892,0.00008610126,0.0003622378,0.0005605638,0.0003730998,0.0003970652,0.0002644564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002500418,"about_ca_system_score_gemma":0.0005518119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140265,"about_ca_topic_score_gemma":0.001230093,"domain_scores_codex":[0.9999089,0.00001513006,0.000004093827,0.0000248463,0.00001545902,0.00003149009],"domain_scores_gemma":[0.9998727,0.00003850193,0.00003207699,0.00001378304,0.00001496369,0.00002789729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005422976,0.0002598058,0.02312682,0.0003351245,0.00009906691,0.000610079,0.0001591944,0.6693577,0.2732196,0.01040589,0.0006915916,0.02119271],"study_design_scores_gemma":[0.000108972,0.0005991529,0.006204067,0.00002984924,0.00009109422,0.0003138502,0.000102151,0.9640417,0.02029311,0.005540179,0.00264978,0.00002614674],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9483527,0.0004202881,0.04643711,0.0001288322,0.00003779437,0.0000346956,0.0001043946,0.0001439474,0.004340359],"genre_scores_gemma":[0.9925644,0.0002386894,0.006036128,0.00007049075,0.000008219254,0.0000457307,0.0000943481,0.00002651452,0.0009155832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0015363,"threshold_uncertainty_score":0.00513947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00966852562723173,"score_gpt":0.198837972347947,"score_spread":0.1891694467207152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}