{"id":"W4391428340","doi":"10.1371/journal.pbio.3002465","title":"Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity","year":2024,"lang":"en","type":"article","venue":"PLoS Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Radboud Universiteit; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"T-cell receptor; Biology; In silico; Antigen; Immunology; Major histocompatibility complex; T cell; Virology; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001425605,0.0003394129,0.0004336248,0.0002346352,0.0005012972,0.00002788138,0.0002315904,0.0005624304,0.001033403],"category_scores_gemma":[0.00001997768,0.0002516897,0.0001095158,0.0002265957,0.0004729342,0.00009332183,0.0001713362,0.0006023488,0.002146008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001503983,"about_ca_system_score_gemma":0.0000827534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003429733,"about_ca_topic_score_gemma":0.00008957617,"domain_scores_codex":[0.9981092,0.0003081302,0.0002672288,0.0006463307,0.00003280245,0.0006363667],"domain_scores_gemma":[0.9993043,0.0002088135,0.0001018833,0.0002930077,0.00006118351,0.00003083747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003295771,0.0002114479,0.008159929,0.00002833401,0.0009563474,0.00002890375,0.00008042491,0.00002394377,0.9805896,0.000936257,0.007548269,0.001106981],"study_design_scores_gemma":[0.002157356,0.003279023,0.0002550007,0.00008366396,0.0001754872,0.00004018164,0.00003830568,0.0001042516,0.920346,0.0001061982,0.07299405,0.000420543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911599,0.004446548,0.0002035544,0.0002113312,0.001431718,0.0003393634,0.0002111304,0.0003850834,0.001611379],"genre_scores_gemma":[0.9955727,0.0009657249,0.00001382848,0.0001574528,0.0001217014,0.00002288409,0.000469166,0.00003403563,0.00264246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06544579,"threshold_uncertainty_score":0.9999936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00966852562723173,"score_gpt":0.198837972347947,"score_spread":0.1891694467207152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}