{"id":"W4391445879","doi":"10.1093/infdis/jiad577","title":"The Purine Biosynthesis Repressor, PurR, Contributes to Vancomycin Susceptibility of Methicillin-resistant <i>Staphylococcus aureus</i> in Experimental Endocarditis","year":2024,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Staphylococcus aureus; Methicillin-resistant Staphylococcus aureus; Microbiology; Vancomycin; Repressor; Endocarditis; Purine; Biosynthesis; Chemistry; Medicine; Biology; Gene; Bacteria; Biochemistry; Transcription factor; Enzyme; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002588918,0.0003421713,0.0003573897,0.0002251141,0.0001372002,0.000381124,0.0002630499,0.0003277658,0.001228458],"category_scores_gemma":[0.0002678618,0.0001701248,0.0002681725,0.0000972995,0.0003177928,0.0001646021,0.0002334722,0.00080294,0.0002522108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003517196,"about_ca_system_score_gemma":0.0002681991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006598155,"about_ca_topic_score_gemma":0.0005900458,"domain_scores_codex":[0.9996569,0.000083144,0.00003324385,0.00006170422,0.00008717099,0.00007790147],"domain_scores_gemma":[0.9996601,0.00005797241,0.0001238652,0.00003722668,0.00002728402,0.00009352817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002065348,0.00006637305,0.0001955104,0.00001646905,0.000002736178,0.00002980914,0.000009636287,0.00003318708,0.9990171,0.00003741871,0.0000163943,0.0003688123],"study_design_scores_gemma":[0.00001999036,0.0008435705,0.004508877,0.000008580838,0.00001509597,0.0002419192,0.00004299828,0.001358657,0.992296,0.00003005327,0.000626845,0.000007222401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973477,0.0004970018,0.001400994,0.00008449506,0.00001618057,0.00001482846,0.0001409434,0.00005104564,0.0004467713],"genre_scores_gemma":[0.9967352,0.0002779044,0.001527399,0.00004192432,0.000008881074,0.00003017393,0.0002749744,0.00002994717,0.001073498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228458,"threshold_uncertainty_score":0.004109561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064767494619139,"score_gpt":0.2885942396261991,"score_spread":0.2779465646800077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}