{"id":"W4391449156","doi":"10.1002/jmv.29445","title":"Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain","year":2024,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Furin; Virology; Ebola virus; Glycoprotein; Viral entry; Biology; Virus; Ebolavirus; Proprotein convertase; Viral envelope; Viral replication; Infectivity; VP40; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001249017,0.0002746442,0.000146455,0.0001004942,0.0000993099,0.0001497921,0.0001592379,0.0001984291,0.001224653],"category_scores_gemma":[0.000193719,0.00006579691,0.0001807041,0.00005367692,0.0001369524,0.000106948,0.000105992,0.0002931835,0.0002689802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275041,"about_ca_system_score_gemma":0.0001571667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002582272,"about_ca_topic_score_gemma":0.0003221836,"domain_scores_codex":[0.9999267,0.00001594194,0.000005097084,0.00001430973,0.00001316641,0.00002480656],"domain_scores_gemma":[0.9999571,0.000007677688,0.00001365119,0.000006536102,0.000003721514,0.0000112436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00106125,0.0001253332,0.0006405216,0.00006086991,0.00001979131,0.0001271842,0.00002306258,0.0001258316,0.9921597,0.0001923427,0.0002428695,0.005221235],"study_design_scores_gemma":[0.0002564594,0.002663462,0.009434579,0.00001052713,0.00005280386,0.001554884,0.00003353768,0.001622463,0.9738272,0.0001806776,0.01035673,0.000006666162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996716,0.001198333,0.001036347,0.00009657471,0.00001442271,0.00002711501,0.0001487285,0.00004023127,0.0007222451],"genre_scores_gemma":[0.9955704,0.0005628653,0.001696343,0.00006278958,0.00001287113,0.00003611019,0.0004798927,0.000008366357,0.00157049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224653,"threshold_uncertainty_score":0.004096925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01623635474081998,"score_gpt":0.3431706083973652,"score_spread":0.3269342536565453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}