{"id":"W4391449156","doi":"10.1002/jmv.29445","title":"Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain","year":2024,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Furin; Virology; Ebola virus; Glycoprotein; Viral entry; Biology; Virus; Ebolavirus; Proprotein convertase; Viral envelope; Viral replication; Infectivity; VP40; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00270738,0.0001492865,0.0004585795,0.0003868457,0.0001364277,0.00004342334,0.0001614545,0.0003468953,0.001526421],"category_scores_gemma":[0.0003689306,0.0001040015,0.0001470081,0.0002175784,0.0003101829,0.0000872517,0.0001692224,0.001782409,0.00006997918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007545965,"about_ca_system_score_gemma":0.0002433493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001095767,"about_ca_topic_score_gemma":0.00003396855,"domain_scores_codex":[0.997564,0.0002512861,0.0006566084,0.0002154038,0.000919559,0.0003931045],"domain_scores_gemma":[0.9989552,0.0001658672,0.00009869339,0.0001123542,0.00007518108,0.0005927269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007619153,0.0005317968,0.002027113,0.0005789979,0.0006004934,0.02004663,0.0005764982,0.000002099334,0.8230904,0.002545215,0.03884343,0.1103955],"study_design_scores_gemma":[0.01087822,0.01301819,0.05792139,0.001638395,0.0004201037,0.04455785,0.000532251,0.002106229,0.03496737,0.009560929,0.8237154,0.0006836404],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695875,0.003856755,0.001675275,0.02298751,0.0004035101,0.0001679482,0.000002470739,0.0000325444,0.001286454],"genre_scores_gemma":[0.9956618,0.0007430318,0.0007217841,0.0009455252,0.001452801,0.000005628418,0.00000216049,0.00002774002,0.0004395624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.788123,"threshold_uncertainty_score":0.9993863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01623635474081998,"score_gpt":0.3431706083973652,"score_spread":0.3269342536565453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}