{"id":"W4391467242","doi":"10.2139/ssrn.4711437","title":"Additive Toxicity From Combined Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors in Patients with Renal or Endometrial Carcinoma: Protocol for a Rapid Systematic Review","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Government of Canada; Health Canada; University of Ottawa","funders":"","keywords":"Tyrosine kinase; Toxicity; Renal carcinoma; Medicine; Cancer research; Carcinoma; Kinase; Oncology; Internal medicine; Pharmacology; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02311725,0.003536866,0.0107039,0.004254349,0.001904843,0.003646651,0.002185154,0.004170815,0.03603883],"category_scores_gemma":[0.04381967,0.002760077,0.0189151,0.00365873,0.001510443,0.003200475,0.004294563,0.004139976,0.003817345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008527705,"about_ca_system_score_gemma":0.01581584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004908425,"about_ca_topic_score_gemma":0.01583633,"domain_scores_codex":[0.9829587,0.007387004,0.005559996,0.001454059,0.001695371,0.0009449212],"domain_scores_gemma":[0.9794925,0.008227707,0.007095987,0.001416349,0.002915457,0.0008519389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.02666456,0.0001736153,0.001211117,0.8827904,0.0265202,0.0002530289,0.0007102496,0.0008921691,0.002577832,0.001330412,0.0196857,0.03719073],"study_design_scores_gemma":[0.1898084,0.005641943,0.01563464,0.4272299,0.1878821,0.0005463761,0.0008832978,0.001328866,0.002875373,0.006417426,0.1611304,0.0006212362],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006727441,0.04454593,0.004850448,0.001991098,0.001394972,0.9180738,0.01837175,0.0006548043,0.003389857],"genre_scores_gemma":[0.02074684,0.01581033,0.01217423,0.002839212,0.0002134727,0.942322,0.003278174,0.0001097171,0.002505974],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03603883,"threshold_uncertainty_score":0.1222572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486389995684882,"score_gpt":0.2667491082052983,"score_spread":0.2518852082484495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}