{"id":"W4391468374","doi":"10.1093/cid/ciad792","title":"A Randomized, Double-Blind, Phase 3 Safety and Efficacy Study of Ridinilazole Versus Vancomycin for Treatment of <i>Clostridioides difficile</i> Infection: Clinical Outcomes With Microbiome and Metabolome Correlates of Response","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Foothills Medical Centre; University of Calgary","funders":"Biomedical Advanced Research and Development Authority; Administration for Strategic Preparedness and Response","keywords":"Vancomycin; Dysbiosis; Internal medicine; Microbiome; Medicine; Clinical endpoint; Antibiotics; Resistome; Clostridium difficile; Gastroenterology; Randomized controlled trial; Microbiology; Biology; Antibiotic resistance; Staphylococcus aureus; Bioinformatics; Disease; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003587979,0.002573323,0.004892247,0.0006034741,0.0007817254,0.001795083,0.001488895,0.00304034,0.008166894],"category_scores_gemma":[0.00420649,0.001210887,0.002451815,0.0006019452,0.002229481,0.001713213,0.0005456205,0.004419217,0.001436253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0012306,"about_ca_system_score_gemma":0.002552143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105016,"about_ca_topic_score_gemma":0.002380412,"domain_scores_codex":[0.997921,0.001245502,0.0001004559,0.0003389342,0.0001560376,0.0002380735],"domain_scores_gemma":[0.9965233,0.0009378665,0.0009853233,0.0003332401,0.0003136143,0.0009067663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9877818,0.005856859,0.0001855857,0.0002051904,0.000399394,0.00001516211,0.00002611195,0.0001214947,0.001630761,0.00004132789,0.0003213374,0.003415002],"study_design_scores_gemma":[0.9441392,0.05413559,0.0006820015,0.00001799788,0.000209686,0.00001773898,0.00001061541,0.0002440203,0.0002108129,0.000085256,0.0002351387,0.0000119789],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746484,0.004034024,0.001750854,0.001078893,0.001065011,0.01239851,0.002136873,0.000295933,0.002591433],"genre_scores_gemma":[0.9710586,0.002044274,0.00355326,0.002160586,0.0008815054,0.0153034,0.001470247,0.00007608155,0.003452012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008166894,"threshold_uncertainty_score":0.02732092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09151149572838492,"score_gpt":0.4425378461261887,"score_spread":0.3510263503978038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}