{"id":"W4391469336","doi":"10.1101/2024.01.30.578077","title":"Both the transcriptional activator, Bcd, and transcriptional repressor, Cic, form small mobile oligomeric clusters in early fly embryo nuclei","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Alliance de recherche numérique du Canada; Universities Space Research Association; McMaster University","keywords":"Drosophila embryogenesis; Repressor; Biology; Transcriptional regulation; Transcription (linguistics); Genetics; Transcription factor; Population; Activator (genetics); Cell biology; Chromatin; Gene; Embryo; YY1; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009011723,0.0001048555,0.0001270382,0.0002383994,0.0002003996,0.0003389515,0.0001592602,0.0001459046,0.0007510712],"category_scores_gemma":[0.0001977998,0.0001153035,0.00009580193,0.0001079602,0.0002542725,0.0001793949,0.0002109086,0.0001840455,0.0002082656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000479986,"about_ca_system_score_gemma":0.0001611771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639608,"about_ca_topic_score_gemma":0.001623575,"domain_scores_codex":[0.9999092,0.000008309874,0.000004927722,0.00003230528,0.00002818544,0.00001720886],"domain_scores_gemma":[0.9998763,0.00001904733,0.00004019481,0.00001332714,0.00002115132,0.00003004395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003898062,0.000003536318,0.0009238635,0.00001481242,0.000003721017,0.00001238895,0.0000228808,0.0001369226,0.9981849,0.0000957963,0.00001292493,0.0005492857],"study_design_scores_gemma":[0.0000153395,0.0001256435,0.04326871,0.00001092695,0.00001584758,0.0002922466,0.0001975997,0.0097687,0.9447212,0.0001583049,0.001411303,0.00001416066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973809,0.0002627242,0.001886313,0.00002007959,0.000002456838,0.000004239618,0.00007937508,0.00001842836,0.0003453617],"genre_scores_gemma":[0.9981346,0.00007810976,0.001090684,0.00001189571,0.000001125468,0.000009143795,0.0001050212,0.00001037341,0.0005591759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639608,"threshold_uncertainty_score":0.003482521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008197154935144354,"score_gpt":0.1996352277735266,"score_spread":0.1914380728383822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}