{"id":"W4391472415","doi":"10.3390/ph17020200","title":"The Effect of a Tribulus-Based Formulation in Alleviating Cholinergic System Impairment and Scopolamine-Induced Memory Loss in Zebrafish (Danio rerio): Insights from Molecular Docking and In Vitro/In Vivo Approaches","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"Tribulus terrestris; Pharmacology; Acetylcholinesterase; Danio; Neuroprotection; In vivo; Aché; Zebrafish; Oxidative stress; Cholinergic; Medicine; Chemistry; Biology; Biochemistry; Neuroscience; Enzyme; Traditional Chinese medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006341427,0.0003770875,0.0002709698,0.0003211409,0.0001405574,0.0001607873,0.0002008312,0.0002282441,0.0007087924],"category_scores_gemma":[0.00006219925,0.00007407214,0.000314548,0.0001221914,0.0001180013,0.0002143994,0.0001308505,0.0003290686,0.0001154562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000183976,"about_ca_system_score_gemma":0.000196636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00138757,"about_ca_topic_score_gemma":0.003546403,"domain_scores_codex":[0.9999727,0.00000303373,0.000002216262,0.00000575186,0.000009660925,0.000006559127],"domain_scores_gemma":[0.9999751,0.000002178982,0.000008448122,0.000001462867,0.000005218683,0.000007617829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001542028,0.00006017181,0.0001030537,0.0001529663,0.00001838347,0.00009323833,0.00001024251,0.0001121897,0.9956408,0.00004742202,0.00006138306,0.003546004],"study_design_scores_gemma":[0.00008015546,0.002774569,0.005609137,0.00003024745,0.0001464292,0.0003352734,0.00005030736,0.001295658,0.9852731,0.00006649152,0.004314221,0.00002446329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989727,0.005954685,0.00189297,0.0001820697,0.00003849069,0.00006983795,0.000357224,0.00008196895,0.001695762],"genre_scores_gemma":[0.9898548,0.004582966,0.003098171,0.0001171451,0.00001104266,0.00004257145,0.0003207597,0.000013793,0.001958851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00138757,"threshold_uncertainty_score":0.002759039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01790751456263142,"score_gpt":0.2872815834689522,"score_spread":0.2693740689063208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}