{"id":"W4391472415","doi":"10.3390/ph17020200","title":"The Effect of a Tribulus-Based Formulation in Alleviating Cholinergic System Impairment and Scopolamine-Induced Memory Loss in Zebrafish (Danio rerio): Insights from Molecular Docking and In Vitro/In Vivo Approaches","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Terry Fox Foundation","keywords":"Tribulus terrestris; Pharmacology; Acetylcholinesterase; Danio; Neuroprotection; In vivo; Aché; Zebrafish; Oxidative stress; Cholinergic; Medicine; Chemistry; Biology; Biochemistry; Neuroscience; Enzyme; Traditional Chinese medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004554607,0.000174088,0.0002924988,0.00007559419,0.00003207277,0.00003361131,0.000074132,0.0001037785,4.82294e-7],"category_scores_gemma":[0.00007189046,0.0001243833,0.00004552727,0.0001811474,0.00006008511,0.00001090681,0.000113332,0.0001701963,8.848934e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007697992,"about_ca_system_score_gemma":0.00002172234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001330034,"about_ca_topic_score_gemma":0.0001463529,"domain_scores_codex":[0.9987417,0.0002015323,0.000359,0.0003379571,0.0001175481,0.0002422923],"domain_scores_gemma":[0.999552,0.0002355861,0.00005355947,0.0001064529,0.000008817307,0.00004364279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005847994,0.00004265995,0.00465182,0.0003651534,0.00003181841,0.00002774831,0.0001537511,0.0002177886,0.9923205,0.00001661142,0.00000148189,0.001585832],"study_design_scores_gemma":[0.001850575,0.0001074414,0.002038386,0.00031903,0.00001649231,0.000002327516,0.0001843967,0.05483695,0.9404442,0.00003595484,0.00003189967,0.0001323462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887478,0.01041183,0.00002306465,0.000150149,0.00004010502,0.0005374621,0.00001166737,0.000007502395,0.00007040745],"genre_scores_gemma":[0.9996116,0.0001520761,0.00002985314,0.00003214837,0.00004202686,0.0001048543,0.00001360395,0.00001301986,8.846086e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05461916,"threshold_uncertainty_score":0.5072203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01790751456263142,"score_gpt":0.2872815834689522,"score_spread":0.2693740689063208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}