{"id":"W4391481439","doi":"10.1016/j.beha.2024.101537","title":"Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders","year":2024,"lang":"en","type":"review","venue":"Best Practice & Research Clinical Haematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Dalhousie University","funders":"National Cancer Institute","keywords":"Penetrance; Germline; Myeloid; CEBPA; Medicine; Disease; ETV6; Germline mutation; Oncology; Biology; Immunology; Internal medicine; Phenotype; Genetics; Mutation; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006497756,0.0004793491,0.001481903,0.00178334,0.0001299878,0.0008235368,0.0009298376,0.000709112,0.002005457],"category_scores_gemma":[0.001829806,0.0001720586,0.0007431191,0.001847136,0.0003166258,0.0006140077,0.0004353356,0.0008870685,0.0005376849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004264799,"about_ca_system_score_gemma":0.0009434965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001297791,"about_ca_topic_score_gemma":0.002121909,"domain_scores_codex":[0.9997001,0.00005391454,0.00006058324,0.00007029924,0.00008846551,0.00002683309],"domain_scores_gemma":[0.9993405,0.0004143108,0.0001198727,0.00001094431,0.00008267679,0.00003172293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000141584,0.00002881018,0.002361634,0.01718456,0.000393683,0.0004193742,0.00004635734,0.0003565878,0.0006762914,0.001645346,0.0133856,0.9633602],"study_design_scores_gemma":[0.0001588872,0.0002553105,0.01787577,0.03858135,0.003322874,0.01471781,0.0002574982,0.0003456343,0.000741978,0.004719116,0.9189401,0.00008366643],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002585425,0.9989181,0.0001138648,0.0002524561,0.00004894023,0.00000265271,0.00003290138,0.000003736977,0.0003689458],"genre_scores_gemma":[0.002398638,0.996805,0.0002371511,0.0002170045,0.000114988,0.000004839396,0.00007357354,0.000001224162,0.0001475761],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002005457,"threshold_uncertainty_score":0.00670892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1496343991511127,"score_gpt":0.5257713301642097,"score_spread":0.3761369310130971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}