{"id":"W4391505599","doi":"10.3390/ijms25031816","title":"Investigating the Role of 17-Beta Estradiol in the Regulation of the Unfolded Protein Response (UPR) in Pancreatic Beta Cells","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Unfolded protein response; BETA (programming language); Beta cell; Endocrinology; Internal medicine; Cell biology; Chemistry; Endoplasmic reticulum; Biology; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002089034,0.0001634005,0.0001715498,0.0001963046,0.0001166226,0.0002723711,0.000118811,0.0001870463,0.0005462463],"category_scores_gemma":[0.00008368009,0.00008609198,0.0002299851,0.0002093251,0.0001993307,0.0002461667,0.0001348367,0.0003211639,0.0001409532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138866,"about_ca_system_score_gemma":0.000160305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001886048,"about_ca_topic_score_gemma":0.0002506966,"domain_scores_codex":[0.9999429,0.00001059654,0.000006253636,0.000011195,0.00001393047,0.00001520861],"domain_scores_gemma":[0.9999393,0.00001328218,0.00002017808,0.000006082821,0.00000847044,0.00001266152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004668889,0.00008802478,0.003993317,0.0001600076,0.00001891074,0.0002489467,0.0000821326,0.00006440945,0.9892413,0.0001755214,0.00003686631,0.00542372],"study_design_scores_gemma":[0.00008162453,0.003672963,0.1044251,0.00006444961,0.0001591667,0.001793351,0.000572009,0.0006635758,0.8752143,0.0005357304,0.01280163,0.00001603274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873474,0.01035308,0.001171622,0.0001531441,0.00004233539,0.00001592995,0.0001207123,0.000008832693,0.0007869989],"genre_scores_gemma":[0.9749252,0.02011782,0.001887756,0.0001800787,0.00005135074,0.00003744424,0.0002727754,0.000007351694,0.002520249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005462463,"threshold_uncertainty_score":0.001827359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008689743741106358,"score_gpt":0.2591662177283837,"score_spread":0.2504764739872773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}