{"id":"W4391521091","doi":"10.1101/2024.02.01.578381","title":"Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"Corpus Christi College, University of Cambridge; Medical Research Council; Blood Cancer UK; University of Oxford; Wellcome Trust; Clarendon Fund; University of Dundee","keywords":"CD8; Cytotoxic T cell; Iron deficiency; Chemistry; Endocrinology; Biology; Biochemistry; Internal medicine; Medicine; Immunology; Immune system; In vitro; Anemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009293717,0.0002850675,0.0001744009,0.0001788302,0.0001110978,0.0002327991,0.0001508414,0.0003654226,0.002108939],"category_scores_gemma":[0.0001020571,0.0001217689,0.0001502101,0.0001194413,0.0002081024,0.00008871251,0.0002433047,0.0005973547,0.0007265977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001771805,"about_ca_system_score_gemma":0.00009327401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002441434,"about_ca_topic_score_gemma":0.0002796263,"domain_scores_codex":[0.9999017,0.00001641674,0.00000975878,0.00002624078,0.00002272796,0.00002311292],"domain_scores_gemma":[0.9999253,0.00001659946,0.00001762372,0.00001087845,0.00000782606,0.00002170991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158225,0.000007772118,0.0002155752,0.00001839028,0.00000208334,0.0001228416,0.000009773312,0.00003156317,0.9987869,0.00005530235,0.00007539086,0.0005586115],"study_design_scores_gemma":[0.00003249872,0.0001977307,0.006466963,0.000007379392,0.00001378764,0.001289247,0.00003866731,0.001131048,0.9860778,0.0002996944,0.004440823,0.000004496693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934028,0.0008454768,0.003156645,0.0002214391,0.00006351946,0.00001339889,0.0005621851,0.0001435313,0.001590964],"genre_scores_gemma":[0.9926124,0.0002734638,0.002335699,0.0001200187,0.0000159816,0.00002508463,0.0008159093,0.00005020221,0.003751238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002108939,"threshold_uncertainty_score":0.007055104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008447295465765085,"score_gpt":0.2146380045642162,"score_spread":0.2061907090984511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}