{"id":"W4391527398","doi":"10.1016/j.esmoop.2024.102233","title":"Trastuzumab deruxtecan in human epidermal growth factor receptor 2-positive breast cancer brain metastases: a systematic review and meta-analysis","year":2024,"lang":"en","type":"review","venue":"ESMO Open","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Society for Medical Oncology; Canada Excellence Research Chairs, Government of Canada; Innovent Biologics; Incyte; Exelixis; AstraZeneca; Amgen; Pfizer; Daiichi Sankyo Europe; Actuate Therapeutics; Bristol-Myers Squibb","keywords":"Medicine; Trastuzumab; Internal medicine; Oncology; Meta-analysis; Breast cancer; Confidence interval; Observational study; Cochrane Library; Cancer; Clinical trial; Hazard ratio; Population","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009078111,0.002249942,0.01470004,0.006526551,0.0004901119,0.002364669,0.001744846,0.00146037,0.003028227],"category_scores_gemma":[0.0189127,0.001170864,0.02538793,0.008413105,0.0004916284,0.00133207,0.001192095,0.001120024,0.0002733284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002574671,"about_ca_system_score_gemma":0.003064138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008109663,"about_ca_topic_score_gemma":0.01859084,"domain_scores_codex":[0.9943685,0.002587603,0.001623118,0.0005772789,0.0006309096,0.0002126575],"domain_scores_gemma":[0.9898543,0.007239072,0.00165443,0.0002868125,0.0008269117,0.0001383992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001389923,0.0000227376,0.002992914,0.535104,0.4456541,0.0001720195,0.00007921321,0.000758002,0.0002667091,0.0001818564,0.00106047,0.01231801],"study_design_scores_gemma":[0.0004378387,0.0001412569,0.003569294,0.04238473,0.9501303,0.0001181784,0.00004261635,0.0002379655,0.0001462876,0.0001808103,0.002587666,0.00002317481],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005242174,0.9926999,0.0003905585,0.0001908704,0.0001003434,0.0002662826,0.0007538616,0.00002348116,0.0003326217],"genre_scores_gemma":[0.1521355,0.8428015,0.001615334,0.000780353,0.0001692302,0.0009968301,0.001045702,0.00002909012,0.0004263983],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01470004,"threshold_uncertainty_score":0.04801023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035190228253845,"score_gpt":0.4221861749337481,"score_spread":0.3186671521083637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}