{"id":"W4391534637","doi":"10.1016/j.archoralbio.2024.105910","title":"The yes-associated protein-1 (YAP1) inhibitor celastrol suppresses the ability of transforming growth factor β to activate human gingival fibroblasts","year":2024,"lang":"en","type":"article","venue":"Archives of Oral Biology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Texas Academy of Science; Arthritis Society","keywords":"Celastrol; Molecular biology; Fibroblast; Chemistry; Transforming growth factor; Western blot; SMAD; Cell biology; Cell culture; Cancer research; Biology; Biochemistry; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195397,0.0001713628,0.0002140304,0.00004622172,0.0001715595,0.00001806077,0.0003632066,0.0001033424,0.000007645389],"category_scores_gemma":[0.0001822315,0.00009881165,0.0001932497,0.00009526245,0.0004385813,0.000004741417,0.0001188324,0.0001702414,0.000001879526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000616218,"about_ca_system_score_gemma":0.00007657352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008683615,"about_ca_topic_score_gemma":0.00005077411,"domain_scores_codex":[0.9987183,0.0002559757,0.000319455,0.0003102766,0.00008080769,0.0003152386],"domain_scores_gemma":[0.9993481,0.0002037692,0.00008278849,0.0002686464,0.0000383449,0.0000583539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000160223,0.00004088541,0.0009301915,0.00005751288,0.0001233411,5.874091e-7,0.00049465,0.000008613237,0.9921731,0.0003855527,0.00001577206,0.005609552],"study_design_scores_gemma":[0.0001989014,0.001029021,0.002904754,0.0000798343,0.00001491054,0.000001582955,0.00007481311,0.00001931018,0.991192,0.00123543,0.003134621,0.0001147499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977638,0.000250554,0.0005780021,0.0004204398,0.000106974,0.0003882135,0.0002447079,0.00002097444,0.0002262997],"genre_scores_gemma":[0.9995041,0.00001875843,0.0001875622,0.00001901787,0.0000806311,0.00003735145,0.00005984421,0.00001802588,0.00007472814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005494803,"threshold_uncertainty_score":0.4029422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100705580095386,"score_gpt":0.2645704677033607,"score_spread":0.2535634119024069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}