{"id":"W4391539431","doi":"10.1016/j.jaci.2023.11.057","title":"Efficacy And Safety Of Bradykinin B2 Receptor Antagonism With Oral Deucrictibant In Prophylaxis Of Hereditary Angioedema Attacks: Results Of CHAPTER-1 Phase 2 Trial","year":2024,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Université de Montréal","funders":"","keywords":"Hereditary angioedema; Antagonism; Bradykinin; Angioedema; Medicine; Pharmacology; Phase (matter); Dermatology; Receptor; Internal medicine; Chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001355287,0.001083787,0.001588029,0.0002550877,0.0003098619,0.0008046953,0.0005789301,0.001213182,0.002039212],"category_scores_gemma":[0.0008665918,0.0002919612,0.001153533,0.0002473887,0.0005669889,0.0006930382,0.0001481403,0.002239952,0.0004082838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006144877,"about_ca_system_score_gemma":0.0006442352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005836019,"about_ca_topic_score_gemma":0.001233094,"domain_scores_codex":[0.9995744,0.0001938893,0.00002577122,0.00006789074,0.00004954701,0.00008851379],"domain_scores_gemma":[0.9995179,0.0001757142,0.0001037407,0.00003668698,0.00002862533,0.0001372745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.747434,0.02701763,0.00468643,0.001188487,0.002507096,0.0002860789,0.0002501286,0.001885875,0.04088505,0.0005838949,0.003403002,0.1698723],"study_design_scores_gemma":[0.6738641,0.3046596,0.01268757,0.00008190992,0.0007867227,0.000321759,0.00004004478,0.0007758823,0.004167085,0.0003075896,0.002274347,0.00003344692],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898005,0.006398211,0.000381377,0.0004273102,0.0001229401,0.0006026793,0.0005573404,0.00005477698,0.001654728],"genre_scores_gemma":[0.9884408,0.0046642,0.001130381,0.0008049122,0.000307124,0.0009331796,0.001336072,0.00002411371,0.00235937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002039212,"threshold_uncertainty_score":0.007167518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03245589746717414,"score_gpt":0.3445807223015415,"score_spread":0.3121248248343674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}