{"id":"W4391542085","doi":"10.1080/23744235.2024.2309348","title":"Variability in plasma rifampicin concentrations and role of <i>SLCO1B1</i> , <i>ABCB1</i> , <i>AADAC2</i> and <i>CES2</i> genotypes in Ethiopian patients with tuberculosis","year":2024,"lang":"en","type":"article","venue":"Infectious Diseases","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European and Developing Countries Clinical Trials Partnership; Fogarty International Center; Addis Ababa University; National Institute for Health and Care Research","keywords":"SLCO1B1; Rifampicin; Medicine; Tuberculosis; Pharmacokinetics; Genotype; Pharmacology; Mycobacterium tuberculosis; Plasma concentration; Virology; Internal medicine; Pharmacogenetics; Biology; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635892,0.000204879,0.0003804234,0.0001659003,0.00004946841,0.0000334767,0.00003857263,0.0001059663,0.00002354846],"category_scores_gemma":[0.00004985487,0.0001626495,0.00004995576,0.0004240824,0.0001887605,0.0001653646,0.00001823388,0.0002132485,0.000001537949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006200727,"about_ca_system_score_gemma":0.0001594914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000359558,"about_ca_topic_score_gemma":0.002139003,"domain_scores_codex":[0.9987021,0.00007223482,0.0003453543,0.0004054072,0.0002295457,0.0002453637],"domain_scores_gemma":[0.9993438,0.0001972754,0.00004518002,0.0001828308,0.00006888593,0.0001619952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001943495,0.0005774206,0.9932457,0.0006114782,0.00005669607,0.00002642588,0.0005953399,0.00003336279,0.001355343,0.00121682,0.00001497641,0.002072047],"study_design_scores_gemma":[0.003165633,0.0003450573,0.9894155,0.0007971476,0.0003123427,0.00001090361,0.0001757718,0.0002863685,0.002381267,0.00183525,0.001016753,0.0002580324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952524,0.001923181,0.00004898667,0.0001649081,0.00009198311,0.0006115379,0.00016849,0.0000822748,0.00165629],"genre_scores_gemma":[0.9991349,0.000404086,0.00008272054,0.0001843651,0.00002905899,0.00005168817,0.00006525502,0.00002524222,0.00002269463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003882541,"threshold_uncertainty_score":0.6632653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001955039721286141,"score_gpt":0.1949170982291897,"score_spread":0.1929620585079035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}