{"id":"W4391542085","doi":"10.1080/23744235.2024.2309348","title":"Variability in plasma rifampicin concentrations and role of <i>SLCO1B1</i> , <i>ABCB1</i> , <i>AADAC2</i> and <i>CES2</i> genotypes in Ethiopian patients with tuberculosis","year":2024,"lang":"en","type":"article","venue":"Infectious Diseases","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European and Developing Countries Clinical Trials Partnership; Fogarty International Center; Addis Ababa University; National Institute for Health and Care Research","keywords":"SLCO1B1; Rifampicin; Medicine; Tuberculosis; Pharmacokinetics; Genotype; Pharmacology; Mycobacterium tuberculosis; Plasma concentration; Virology; Internal medicine; Pharmacogenetics; Biology; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005115816,0.0001926442,0.0002896799,0.0002493419,0.0001482666,0.0004359529,0.0001658924,0.000237056,0.0006126757],"category_scores_gemma":[0.001329545,0.0001363704,0.0001522609,0.000323368,0.0001733702,0.0001510719,0.0001697936,0.0002117173,0.00013133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002332868,"about_ca_system_score_gemma":0.0001108477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007908123,"about_ca_topic_score_gemma":0.0008102367,"domain_scores_codex":[0.9995781,0.0001206848,0.00005876092,0.0001487487,0.00005252266,0.00004123951],"domain_scores_gemma":[0.9989697,0.0003914191,0.0004100988,0.00007344965,0.00007978627,0.00007560174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001168221,0.00004526368,0.9870351,0.00003792114,0.0001063985,0.0002921951,0.0002217722,0.0002521766,0.006052873,0.00003093921,0.0001048413,0.004652309],"study_design_scores_gemma":[0.00002689431,0.0004131273,0.994463,0.00001709847,0.00006671804,0.001734715,0.0002590519,0.0007160283,0.001810438,0.00005316928,0.0004298436,0.000009895617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994214,0.0002681013,0.00009660642,0.00000948152,0.000001859584,0.000002567816,0.000110612,0.000001506023,0.00008798019],"genre_scores_gemma":[0.9997136,0.00005034613,0.00008525222,0.00001242118,0.000002650861,0.000002373363,0.00009990824,0.00000119757,0.00003216739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007908123,"threshold_uncertainty_score":0.002705574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001955039721286141,"score_gpt":0.1949170982291897,"score_spread":0.1929620585079035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}