{"id":"W4391542739","doi":"10.1101/gad.350740.123","title":"DNA damage remodels the MITF interactome to increase melanoma genomic instability","year":2024,"lang":"en","type":"article","venue":"Genes & Development","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Medical Research Council; Medical Research Council Canada; Fonds de Recherche du Québec - Santé; Marie Curie; Ludwig Institute for Cancer Research; Cancer Research Society; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Microphthalmia-associated transcription factor; Biology; Genome instability; DNA damage; DNA repair; Transcription factor; Genetics; Cell biology; Rad50; Cancer research; DNA; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080806,0.0003381943,0.0001942969,0.0002595019,0.0001858738,0.000317586,0.0002496025,0.000418475,0.003261417],"category_scores_gemma":[0.0001097242,0.0001550804,0.0002135261,0.00009471643,0.0002174175,0.0001668797,0.000352647,0.0004936805,0.0007028499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003990309,"about_ca_system_score_gemma":0.0002027991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005013511,"about_ca_topic_score_gemma":0.001545188,"domain_scores_codex":[0.9998616,0.00001393638,0.00001007076,0.00003661827,0.00003874934,0.00003909558],"domain_scores_gemma":[0.9998822,0.00001698697,0.00003884919,0.00001534214,0.000006369839,0.00004026253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003964194,0.00002342232,0.0002270592,0.00002176176,0.000004190952,0.00007610951,0.0000122674,0.00007617871,0.9977882,0.0002095429,0.0001025655,0.001419168],"study_design_scores_gemma":[0.00002358383,0.0001202513,0.008228898,0.00001040242,0.00001417066,0.0006722196,0.00003824834,0.001871324,0.9784127,0.000137469,0.01046152,0.000009239243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858518,0.0008740331,0.007666802,0.0003304629,0.00007223548,0.00005514979,0.0005649817,0.0005239358,0.004060676],"genre_scores_gemma":[0.9917265,0.0002916957,0.003942322,0.0001037701,0.00001036946,0.00002925242,0.0002523671,0.00006612265,0.003577572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003261417,"threshold_uncertainty_score":0.01091051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008415406925139004,"score_gpt":0.2776999010261688,"score_spread":0.2692844941010298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}