{"id":"W4391545301","doi":"10.1016/j.ebiom.2024.104991","title":"Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis","year":2024,"lang":"en","type":"review","venue":"EBioMedicine","topic":"Inflammatory Biomarkers in Disease Prognosis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Institute of Cancer Research","funders":"Department of Epidemiology and Biostatistics, University of California, San Francisco; Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; School of Public Health, Imperial College London; Wageningen University and Research; Instituto de Salud Carlos III; Medical Research Council; Canadian Cancer Society Research Institute; Biobanco Vasco; Junta de Castilla y León; Xunta de Galicia; World Cancer Research Fund; Region Skåne; National Institute for Health and Care Research; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Memorial Sloan-Kettering Cancer Center; Centre International de Recherche sur le Cancer; Institut National Du Cancer; National Health and Medical Research Council; Deutsche Krebshilfe; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; University of Maryland School of Public Health; Conseil Régional des Pays de la Loire; Vetenskapsrådet; Ligue Contre le Cancer; Canadian Institutes of Health Research; European Commission; Knut och Alice Wallenbergs Stiftelse; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; Ministry of Health, Labour and Welfare; University Hospitals Bristol NHS Foundation Trust; Consejería de Educación, Junta de Castilla y León; Mutuelle Générale de l'Education Nationale; Ministerie van Volksgezondheid, Welzijn en Sport; Cancerfonden; Fundación Científica Asociación Española Contra el Cáncer; Ministerio de Economía y Competitividad; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Academy of Finland; Cancer Council Victoria; Medizinische Universität Graz; Institut Gustave-Roussy; Herzfelder'sche Familienstiftung; Grantová Agentura České Republiky; Emory University; VicHealth; Florida Department of Health; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Association Anne de Bretagne Genetique; Centre Hospitalier Universitaire de Nantes; NIHR Imperial Biomedical Research Centre; Univerzita Karlova v Praze; McGill University; Ontario Research Foundation; Generalitat de Catalunya; Imperial College London; Food Standards Agency; National Cancer Institute; European Regional Development Fund; European Cooperation in Science and Technology; Génome Québec; Institut National de la Santé et de la Recherche Médicale; Matthias Lackas-Stiftung; Moffitt Cancer Center; Umeå Universitet; Chonnam National University; Centres de Recerca de Catalunya; Consejería de Salud y Familias, Junta de Andalucía; Canadian Cancer Society; Johns Hopkins University; National Institute on Aging; NIHR Bristol Biomedical Research Centre; Office of Research Infrastructure Programs, National Institutes of Health; State of Maryland; Österreichische Forschungsförderungsgesellschaft; University of South Florida; American Institute for Cancer Research; Ministerstvo Zdravotnictví Ceské Republiky; Pelotonia; Deutsche Forschungsgemeinschaft; University of Iowa; National Cancer Center; Ontario Ministry of Research, Innovation and Science; Deutsches Krebsforschungszentrum; Harvard T.H. Chan School of Public Health; Kræftens Bekæmpelse; Victorian Cancer Agency; University of Cambridge; Stockholms Läns Landsting; University of Pittsburgh; Lung Cancer Research Foundation; Mike and Josie Harper Cancer Research Institute; National Heart and Lung Institute; Eno Scientific Foundation; Agència de Gestió d'Ajuts Universitaris i de Recerca; Versus Arthritis; Maryland Department of Health; National Research Council; Marshfield Clinic Research Foundation; Albert Einstein Cancer Center; Cancer Research UK; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Wereld Kanker Onderzoek Fonds; Brigham and Women's Hospital; Karl-Franzens-Universität Graz; University of Bristol; Damon Runyon Cancer Research Foundation; U.S. Department of Health and Human Services; American Cancer Society","keywords":"Mendelian randomization; Medicine; Cancer; Oncology; Bioinformatics; Genetics; Internal medicine; Biology; Genotype; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07110141,0.00270142,0.007326898,0.004052375,0.001404928,0.001995268,0.003285555,0.002770357,0.008802918],"category_scores_gemma":[0.08037354,0.001544915,0.01442215,0.004351663,0.001822866,0.001268175,0.001920546,0.002391565,0.0007368185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00106999,"about_ca_system_score_gemma":0.001944374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005113732,"about_ca_topic_score_gemma":0.00246915,"domain_scores_codex":[0.9013153,0.07592949,0.00347318,0.01335401,0.004179402,0.001748704],"domain_scores_gemma":[0.934998,0.05007827,0.00383217,0.008866695,0.001519432,0.0007054575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.09633265,0.001101861,0.3656305,0.004140852,0.2959103,0.007473856,0.001191638,0.07876889,0.01656225,0.03195462,0.007656436,0.09327617],"study_design_scores_gemma":[0.01686165,0.01020711,0.1347941,0.0005283661,0.1620316,0.004845401,0.0003484302,0.6200655,0.003748669,0.03532716,0.01070304,0.000539014],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4983385,0.007991936,0.4819824,0.0009405201,0.0004618101,0.00337128,0.003161363,0.00166961,0.002082618],"genre_scores_gemma":[0.8985071,0.0007878435,0.09520902,0.0002455862,0.0001187145,0.002713431,0.001128113,0.0001846087,0.001105619],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.07110141,"threshold_uncertainty_score":0.3760247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784502259469795,"score_gpt":0.3317655683888552,"score_spread":0.3139205457941572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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