{"id":"W4391557465","doi":"10.1016/j.celrep.2024.113744","title":"Peroxisome deficiency underlies failures in hepatic immune cell development and antigen presentation in a severe Zellweger disease model","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; Beatrice Hunter Cancer Research Institute; Dalhousie University; University of Alberta","funders":"Université de Bourgogne","keywords":"Peroxisome; Biology; Zellweger syndrome; Biogenesis; Antigen presentation; Immune system; Plasmacytoid dendritic cell; Peroxisomal disorder; Dendritic cell; Cell biology; Antigen processing; Antigen; Haematopoiesis; Immunology; T cell; Stem cell; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002297245,0.0008476623,0.0003170768,0.001067142,0.0002496261,0.0003454664,0.000278124,0.0005834879,0.002554321],"category_scores_gemma":[0.0002545983,0.0002480087,0.0002542429,0.0002424928,0.0005999817,0.0003158185,0.0004924036,0.0006770417,0.0004546777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742588,"about_ca_system_score_gemma":0.0002116677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003309699,"about_ca_topic_score_gemma":0.0003868719,"domain_scores_codex":[0.9997625,0.00004305439,0.00003479051,0.00008450955,0.00004119208,0.00003393983],"domain_scores_gemma":[0.9997085,0.00004066396,0.00009403148,0.00003664823,0.00001357603,0.000106591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007139068,0.0001370593,0.002509344,0.00006336177,0.00002919511,0.002147008,0.00008443481,0.0002824655,0.9907572,0.0008182633,0.0001568539,0.002300902],"study_design_scores_gemma":[0.0002387275,0.001756807,0.05308113,0.00007902177,0.000184739,0.02172514,0.0004033126,0.005816008,0.9051239,0.002329521,0.009212087,0.00004950039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994626,0.0004875656,0.003050386,0.0001062068,0.00002016954,0.0000335319,0.0004675179,0.0001093302,0.001099236],"genre_scores_gemma":[0.9944436,0.0005636655,0.002004999,0.00004344758,0.00001200994,0.00005200461,0.0004738956,0.00004606614,0.002360317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002554321,"threshold_uncertainty_score":0.008545101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095462981614427,"score_gpt":0.2297870922565302,"score_spread":0.2188324624403859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}