{"id":"W4391565041","doi":"10.1083/jcb.202305026","title":"TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression","year":2024,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Biophysics, Chinese Academy of Sciences; Institute of Genetics; Tianjin Medical University; National Natural Science Foundation of China; National Key Research and Development Program of China; State Key Laboratory of Molecular Biology; Directorate for Biological Sciences; Chinese Academy of Sciences; Memorial Sloan-Kettering Cancer Center","keywords":"Downregulation and upregulation; IRF1; Programmed cell death; Tumor necrosis factor alpha; Cell biology; Caspase 8; Biology; Cancer research; Apoptosis; Caspase; Caspase 1; Immune checkpoint; Cancer immunotherapy; Transcription factor; Immunotherapy; Immunology; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195455,0.0002996697,0.0002206032,0.0002084891,0.0001951703,0.0003174404,0.0001759664,0.0003096924,0.002428219],"category_scores_gemma":[0.00009947671,0.0001387611,0.0003707749,0.0001245894,0.0002236794,0.0002894886,0.0002872476,0.0006830407,0.0009384647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004984988,"about_ca_system_score_gemma":0.0002349747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002193347,"about_ca_topic_score_gemma":0.0003652953,"domain_scores_codex":[0.9997727,0.00003305526,0.00001972661,0.00005007697,0.00005763296,0.00006666179],"domain_scores_gemma":[0.9999032,0.00001233653,0.00003723623,0.0000150497,0.00001163033,0.00002053985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009045915,0.00002061753,0.0002663216,0.00002513769,0.00000330549,0.00005226554,0.00001031808,0.0000549949,0.9976687,0.0001558753,0.00003868029,0.001613234],"study_design_scores_gemma":[0.00001615188,0.0001135437,0.003109951,0.000006935867,0.000007108009,0.0004313927,0.00002947925,0.0005954634,0.9925982,0.000100628,0.002987471,0.000003675256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842391,0.002477332,0.009174484,0.0002394299,0.00004699759,0.00003545846,0.000849253,0.0001963188,0.002741562],"genre_scores_gemma":[0.9919866,0.0004492157,0.003913509,0.00007096009,0.000007466809,0.00002834491,0.0009490657,0.00002501575,0.002569808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002428219,"threshold_uncertainty_score":0.008123279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009388440793604912,"score_gpt":0.2535840957104727,"score_spread":0.2441956549168678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}