{"id":"W4391565851","doi":"10.1038/s41420-024-01826-6","title":"Dependence of human cell survival and proliferation on the CASP3 prodomain","year":2024,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Terry Fox Research Institute; University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Cell growth; Cell biology; Cell cycle; Biology; Intracellular; Cell; Gene knockdown; Apoptosis; Programmed cell death; Flow cytometry; Biochemistry; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642202,0.000416202,0.0002385779,0.0002796079,0.000121684,0.000282029,0.0002187137,0.0002455101,0.006310635],"category_scores_gemma":[0.0001714824,0.0001303131,0.0002702856,0.0002970998,0.0001281837,0.0001866451,0.0002141428,0.0006554945,0.001754762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331571,"about_ca_system_score_gemma":0.0002143955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006695052,"about_ca_topic_score_gemma":0.001011428,"domain_scores_codex":[0.999849,0.0000157198,0.000007246044,0.00004201994,0.00005715349,0.00002876561],"domain_scores_gemma":[0.9999537,0.0000143272,0.00001360926,0.000004920193,0.000007374387,0.000006041722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004459002,0.00004335499,0.0003837517,0.0004795235,0.00002010511,0.0001517041,0.00003888452,0.001043996,0.9679148,0.0009155305,0.002204498,0.02635797],"study_design_scores_gemma":[0.00003481894,0.0004200975,0.003999499,0.00003483963,0.00003220339,0.0002262569,0.00001979642,0.001915318,0.9744515,0.0006069867,0.01824212,0.00001652191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8315449,0.04889099,0.04176049,0.002645246,0.0006865532,0.000315047,0.02208719,0.002642192,0.04942739],"genre_scores_gemma":[0.9624255,0.01163079,0.008631473,0.0003151082,0.00005824392,0.0002043541,0.005740399,0.0001172429,0.01087685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006310635,"threshold_uncertainty_score":0.02111119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943899688399954,"score_gpt":0.2500137982217967,"score_spread":0.2305748013377972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}