{"id":"W4391573849","doi":"10.1038/s41467-024-45449-y","title":"Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Terry Fox Research Institute; Merck Canada; Terry Fox Foundation","keywords":"TIGIT; Merkel cell carcinoma; Blockade; Pembrolizumab; Cancer research; Cytotoxic T cell; Immunotherapy; CD8; T cell; Merkel cell polyomavirus; T-cell receptor; Immunology; Medicine; Antigen; Biology; Carcinoma; Immune system; Internal medicine; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009893616,0.0002345376,0.0002633849,0.0002361628,0.0003376468,0.0003026065,0.0001423276,0.0004064931,0.001124911],"category_scores_gemma":[0.000299429,0.0001078796,0.0002024301,0.0001046274,0.0001603813,0.0001701689,0.0001428697,0.0006047215,0.000224374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002823806,"about_ca_system_score_gemma":0.0001327358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005945241,"about_ca_topic_score_gemma":0.0008045638,"domain_scores_codex":[0.9999274,0.000009411448,0.000008708591,0.00002022523,0.00001233529,0.00002196944],"domain_scores_gemma":[0.999805,0.00005452823,0.00002699842,0.00002135657,0.00001679356,0.00007518992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.003765679,0.0006956037,0.1787242,0.0001829002,0.00008834243,0.2164009,0.001240328,0.0009805113,0.5484324,0.0005734723,0.001418977,0.04749679],"study_design_scores_gemma":[0.0001489759,0.004532938,0.3542551,0.00005662097,0.000181799,0.4986174,0.000675288,0.004331015,0.1292762,0.0005391354,0.007341414,0.00004416211],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973691,0.0002713328,0.0002509225,0.0001705852,0.00001141749,0.00001972333,0.00005783712,0.0000386932,0.001810421],"genre_scores_gemma":[0.9991509,0.00006691828,0.0001604735,0.00007885945,0.000008170449,0.000003631875,0.00003518706,0.000003574007,0.0004922644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124911,"threshold_uncertainty_score":0.003763199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01527544852179876,"score_gpt":0.2990300956426041,"score_spread":0.2837546471208053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}