{"id":"W4391577022","doi":"10.1128/aac.01072-23","title":"Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting “block and lock” treatment strategies","year":2024,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Provirus; Kinase; Biology; Cyclin-dependent kinase; Virology; Cancer research; Cell cycle; Cell biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198017,0.0003102204,0.0002574692,0.0001748832,0.0001365552,0.0002812476,0.0001791642,0.0001410658,0.001549244],"category_scores_gemma":[0.00009813505,0.0001021272,0.00017259,0.0001032608,0.0002301365,0.0002463334,0.0001593987,0.0005924804,0.0003138934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798426,"about_ca_system_score_gemma":0.0002439638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610469,"about_ca_topic_score_gemma":0.0008998142,"domain_scores_codex":[0.9999275,0.00001309847,0.000004782124,0.00001213863,0.00002305839,0.0000194703],"domain_scores_gemma":[0.9999564,0.00001248109,0.00001036524,0.000005425891,0.000007258422,0.000008090045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002352549,0.0001330549,0.0002493648,0.0001435093,0.00001554326,0.00006444219,0.0000174767,0.0003432655,0.9750007,0.001596632,0.0003399776,0.02186066],"study_design_scores_gemma":[0.0001154853,0.001860902,0.001685998,0.00001644653,0.00003178811,0.0003173,0.00002438044,0.001293797,0.9767535,0.0002981062,0.01759397,0.000008276401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.948767,0.02623998,0.01091566,0.0004866674,0.0001927589,0.0002496585,0.0004291611,0.000287125,0.01243205],"genre_scores_gemma":[0.9774484,0.01249205,0.00485697,0.0001908889,0.00004640933,0.0001167191,0.0002236228,0.00001594198,0.004609145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549244,"threshold_uncertainty_score":0.005182743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201293468994401,"score_gpt":0.2616715272638104,"score_spread":0.2415421803643703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}