{"id":"W4391579477","doi":"10.21203/rs.3.rs-3461290/v1","title":"Genome-wide association analysis identifies PLA2G4C as a susceptibility locus for Multiple System Atrophy","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Koning Boudewijnstichting; Seoul National University Hospital; National Research Foundation of Korea; National Research Foundation; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Guarantors of Brain; Seoul National University; RIKEN; Japan Agency for Medical Research and Development","keywords":"Locus (genetics); Genetics; Genome-wide association study; Genetic association; Genome; Biology; Atrophy; Computational biology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009058603,0.0006827651,0.0004715001,0.001151984,0.0004785476,0.0005943392,0.0004245114,0.000550551,0.002275761],"category_scores_gemma":[0.001066107,0.0002281061,0.001051906,0.001644705,0.0003969606,0.000130916,0.0003821629,0.000562884,0.000175563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002623418,"about_ca_system_score_gemma":0.0004123482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00873066,"about_ca_topic_score_gemma":0.00682337,"domain_scores_codex":[0.9995425,0.0001559796,0.00003707556,0.0001553834,0.00007024105,0.00003889333],"domain_scores_gemma":[0.9994094,0.0001638324,0.0001883264,0.00005875128,0.00008419739,0.00009534056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002545782,0.000102616,0.9373643,0.0001485425,0.00543563,0.002151222,0.0001077917,0.0005751105,0.04291996,0.000166126,0.0008100491,0.007672844],"study_design_scores_gemma":[0.0001372405,0.0001325527,0.9927663,0.00001460807,0.001843246,0.000764562,0.00007606634,0.001486674,0.00185379,0.0001614695,0.0007514359,0.00001204962],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954225,0.002401319,0.001125722,0.000204507,0.00002992696,0.00001572507,0.0003835845,0.00004554873,0.0003711307],"genre_scores_gemma":[0.9986149,0.0002990402,0.0005840457,0.00005671613,0.00002827781,0.000008756225,0.0002348017,0.000007307788,0.0001660294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00873066,"threshold_uncertainty_score":0.01735967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07110784981843574,"score_gpt":0.3820137919345398,"score_spread":0.3109059421161041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}