{"id":"W4391592373","doi":"10.1093/nar/gkae051","title":"Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2","year":2024,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Gobierno de Aragón; Ministerio de Ciencia e Innovación; Ministerio de Economía y Competitividad","keywords":"Biology; MECP2; Epigenetics; Histone; Rett syndrome; Genetics; Chromatin; Regulator; Histone code; Epigenomics; Histone methylation; Regulation of gene expression; Computational biology; DNA methylation; Cell biology; Nucleosome; Gene; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645658,0.0006362746,0.0002621418,0.0005833146,0.0004690134,0.0009244385,0.0003781884,0.0004596405,0.00867994],"category_scores_gemma":[0.0003726805,0.0002092898,0.0002747817,0.0005500459,0.0001846537,0.0009294231,0.001080555,0.0005175803,0.004741807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004747805,"about_ca_system_score_gemma":0.0002407826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007330847,"about_ca_topic_score_gemma":0.001729097,"domain_scores_codex":[0.9998348,0.00001569816,0.000009472849,0.00004455718,0.00006524588,0.00003033914],"domain_scores_gemma":[0.9998664,0.00002890885,0.0000237704,0.00001480453,0.00002670935,0.00003944534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005907067,0.00003803318,0.01086509,0.001080868,0.0001065259,0.002702891,0.0003777611,0.0004686076,0.8360573,0.006754867,0.04372289,0.09723433],"study_design_scores_gemma":[0.00004394335,0.0001023365,0.06581149,0.0002850922,0.0001436942,0.008551314,0.0003813038,0.003365564,0.3110386,0.007441778,0.6027594,0.00007557967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6080867,0.1535757,0.04707824,0.01502036,0.003470574,0.0001145232,0.02169012,0.00586963,0.1450941],"genre_scores_gemma":[0.7786884,0.05989465,0.03707579,0.005482504,0.001774261,0.0001486831,0.02178386,0.0009104617,0.09424138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00867994,"threshold_uncertainty_score":0.02903724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02942582595477124,"score_gpt":0.346214204046306,"score_spread":0.3167883780915348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}