{"id":"W4391594268","doi":"10.1093/braincomms/fcae031","title":"Tau accumulation and its spatial progression across the Alzheimer’s disease spectrum","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; IXICO; Servier; Lundbeckfonden; Janssen Alzheimer Immunotherapy Research And Development; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Takeda Pharmaceutical Company; AbbVie; National Institute on Aging; Fujirebio Europe; Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Merck; Eli Lilly and Company; GE Healthcare; BioClinica; Alzheimer's Disease Neuroimaging Initiative","keywords":"Disease; Alzheimer's disease; Neuroscience; Psychology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000293604,0.0001189197,0.0001138449,0.00006075262,0.0008449623,0.0000635385,0.0003017955,0.00003506144,0.00004216639],"category_scores_gemma":[0.0002883766,0.00008204887,0.00006642348,0.0003590845,0.0002024577,0.0001146123,0.000517905,0.000183542,0.000255417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002837484,"about_ca_system_score_gemma":0.0001777523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005802381,"about_ca_topic_score_gemma":0.00008320103,"domain_scores_codex":[0.998839,0.0001848494,0.0001647631,0.0001986818,0.0003118515,0.0003008895],"domain_scores_gemma":[0.9977587,0.0004406176,0.00005807931,0.001279486,0.00007275044,0.0003903779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002951927,0.004800532,0.6522794,0.0003292765,0.01295321,0.0004691583,0.006597609,0.0001999355,0.0004769965,0.02678551,0.0480977,0.2440587],"study_design_scores_gemma":[0.001113375,0.00007047808,0.9579715,0.0001077138,0.0003358035,0.000005718668,0.000149529,0.03151886,0.00007621229,0.001519719,0.007016492,0.0001145843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6171833,0.04684029,0.00004256461,0.3306976,0.000091186,0.003353184,0.0003322118,0.0005209898,0.0009386528],"genre_scores_gemma":[0.996964,0.001330093,0.00006425902,0.0003278893,0.00007384554,0.0002952458,0.0008017188,0.00002327388,0.0001197117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3797806,"threshold_uncertainty_score":0.6498852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1481420816966812,"score_gpt":0.4589975055736114,"score_spread":0.3108554238769302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}